{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360869864321815552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s10787-022-01005-y"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s10787-022-01005-y.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s10787-022-01005-y/fulltext.html"}}],"dc:title":[{"@value":"Novel anti-arthritic mechanisms of trans-cinnamaldehyde against complete Freund’s adjuvant-induced arthritis in mice: involvement of NF-кB/TNF-α and IL-6/IL-23/ IL-17 pathways in the immuno-inflammatory responses"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Trans-cinnamaldehyde (TCA), a natural cinnamaldehyde derivative of cinnamon oil, is known for anti-inflammatory, anti-bacterial, anti-fungal, anti-diabetic, and anti-cancer activities. However, no study has examined the protective mechanisms of TCA on complete Freund’s adjuvant (CFA)-induced arthritis. Chronic arthritis was induced in mice by triple dose injection of 0.1 ml CFA in the first two days, then a treatment with TCA (100 mg/kg, i.p.) and the anti-arthritic drug; methotrexate (MTX, 0.75 mg/kg, i.p., 3 times/week) started from day 10 after CFA and continued till day 35.TCA ameliorated the CFA-induced arthritis features, indicated by the decrease in serum rheumatoid factor, paw swelling, arthritis index and the arthritis changes in limb histology. Additionally, TCA treatment showed anti-inflammatory actions through downregulation of TNF-α, NF-κB and COX-2 expressions and marked reduction in IL-1β, IL-6, IL-23 and IL-17 levels in inflamed paw tissues.Consequently, TCA can decrease arthritis progression and inhibit the immune/inflammatory responses initiated by TNF-α/IL-1β/IL-6/IL-23/IL-17 signals, via NF-κB modulation, almost to the same extent accomplished by MTX. Therefore, TCA could be a promising anti-arthritic drug.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380869864321815553","@type":"Researcher","foaf:name":[{"@value":"Ghada S. El-Tanbouly"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869864321815552","@type":"Researcher","foaf:name":[{"@value":"Rehab S. Abdelrahman"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09254692"},{"@type":"EISSN","@value":"15685608"}],"prism:publicationName":[{"@value":"Inflammopharmacology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2022-06-01","prism:volume":"30","prism:number":"5","prism:startingPage":"1769","prism:endingPage":"1780"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1007/s10787-022-01005-y.pdf"},{"@id":"https://link.springer.com/article/10.1007/s10787-022-01005-y/fulltext.html"}],"createdAt":"2022-06-01","modifiedAt":"2022-09-22","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360025431138641792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"γCyclodextrin-assisted Aqueous Extract of Cinnamon for Cancer and Stress Management"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s10787-022-01005-y"},{"@type":"CROSSREF","@value":"10.2174/0115680266309291240808114508_references_DOI_XnWuy3lW4nK4VWVZ49XtnPnMVTe"}]}