{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361131416633658368.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.celrep.2020.01.103"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2211124720301376?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2211124720301376?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"32101749"}},{"identifier":{"@type":"HANDLE","@value":"11250/2763785"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s"}],"description":[{"notation":[{"@value":"Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune cells. Here, we show, using melanoma as a model, that while the IL-33/IL C2/eosinophil axis suppresses tumor growth, tumor-derived lactate attenuates the function and survival of ILC2s. Melanomas with reduced lactate production (LDHA"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381131416633658372","@type":"Researcher","foaf:name":[{"@value":"Marek Wagner"}]},{"@id":"https://cir.nii.ac.jp/crid/1381131416633658370","@type":"Researcher","foaf:name":[{"@value":"Kafi N. Ealey"}]},{"@id":"https://cir.nii.ac.jp/crid/1381131416633658374","@type":"Researcher","foaf:name":[{"@value":"Hiroe Tetsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133632942080","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90793795"},{"@type":"NRID","@value":"1000090793795"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tkiniwa"}],"foaf:name":[{"@value":"Tsuyoshi Kiniwa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381131416633658371","@type":"Researcher","foaf:name":[{"@value":"Yasutaka 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Koyasu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"22111247"}],"prism:publicationName":[{"@value":"Cell Reports"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2020-02","prism:volume":"30","prism:number":"8","prism:startingPage":"2743","prism:endingPage":"2757.e5"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2211124720301376?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2211124720301376?httpAccept=text/plain"}],"createdAt":"2020-02-25","modifiedAt":"2025-10-31","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=570","dc:title":"570"},{"@id":"https://cir.nii.ac.jp/all?q=Skin%20Neoplasms","dc:title":"Skin 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