{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137043515096960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000445355"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/445355"}}],"dc:title":[{"@value":"Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><b><i>Background:</i></b> Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults. <b><i>Methods:</i></b> This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models. <b><i>Results:</i></b> A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signi&#xFB01;cantly between groups (t<sub>825</sub> = 6.12, p < 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was <i>d</i> = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with <i>d</i> = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10). <b><i>Conclusions:</i></b> The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137043515096838","@type":"Researcher","foaf:name":[{"@value":"Jan Philipp Klein"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096834","@type":"Researcher","foaf:name":[{"@value":"Thomas Berger"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096964","@type":"Researcher","foaf:name":[{"@value":"Johanna Schröder"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096963","@type":"Researcher","foaf:name":[{"@value":"Christina Späth"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096960","@type":"Researcher","foaf:name":[{"@value":"Björn Meyer"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096961","@type":"Researcher","foaf:name":[{"@value":"Franz Caspar"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096967","@type":"Researcher","foaf:name":[{"@value":"Wolfgang Lutz"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096832","@type":"Researcher","foaf:name":[{"@value":"Alice Arndt"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096840","@type":"Researcher","foaf:name":[{"@value":"Wolfgang Greiner"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096965","@type":"Researcher","foaf:name":[{"@value":"Viola Gräfe"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096837","@type":"Researcher","foaf:name":[{"@value":"Martin Hautzinger"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096966","@type":"Researcher","foaf:name":[{"@value":"Kristina Fuhr"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096835","@type":"Researcher","foaf:name":[{"@value":"Matthias Rose"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096841","@type":"Researcher","foaf:name":[{"@value":"Sandra Nolte"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096962","@type":"Researcher","foaf:name":[{"@value":"Bernd Löwe"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096839","@type":"Researcher","foaf:name":[{"@value":"Gerhard Andersson"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096833","@type":"Researcher","foaf:name":[{"@value":"Eik Vettorazzi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096968","@type":"Researcher","foaf:name":[{"@value":"Steffen Moritz"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043515096836","@type":"Researcher","foaf:name":[{"@value":"Fritz Hohagen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00333190"},{"@type":"EISSN","@value":"14230348"}],"prism:publicationName":[{"@value":"Psychotherapy and Psychosomatics"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2016","prism:volume":"85","prism:number":"4","prism:startingPage":"218","prism:endingPage":"228"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by-nc/4.0/","https://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://www.karger.com/Article/Pdf/445355"}],"createdAt":"2016-05-26","modifiedAt":"2025-04-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050013629440742784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Components of smartphone cognitive-behavioural therapy for subthreshold depression among 1093 university students: a factorial trial"},{"@value":"Components of smartphone cognitive-behavioral therapy for subthreshold depression among 1093 university students: A factorial trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617610991616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Internet-Based Cognitive Behavioral Therapy for Depression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182038768896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567350415232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000445355"},{"@type":"CROSSREF","@value":"10.1001/jamapsychiatry.2020.4364_references_DOI_8q4kK6ZAXqYVD5qcQnnFCbPlmIK"},{"@type":"CROSSREF","@value":"10.1136/ebmental-2022-300455_references_DOI_8q4kK6ZAXqYVD5qcQnnFCbPlmIK"},{"@type":"CROSSREF","@value":"10.1159/000507819_references_DOI_8q4kK6ZAXqYVD5qcQnnFCbPlmIK"},{"@type":"CROSSREF","@value":"10.1016/j.cpr.2018.06.007_references_DOI_8q4kK6ZAXqYVD5qcQnnFCbPlmIK"}]}