{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137043579892736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0304-3835(01)00635-8"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304383501006358?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304383501006358?httpAccept=text/xml"}},{"identifier":{"@type":"PMID","@value":"11566483"}}],"dc:title":[{"@value":"Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L."}],"description":[{"notation":[{"@value":"Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester and capsorbin diester showed strong inhibitory effects. Furthermore, capsanthin , capsanthin 3'-ester and capsanthin 3,3'-diester , major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137043579892745","@type":"Researcher","foaf:name":[{"@value":"Takashi Maoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043579892737","@type":"Researcher","foaf:name":[{"@value":"Kooich Mochida"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043579892738","@type":"Researcher","foaf:name":[{"@value":"Mutsuo Kozuka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043579892746","@type":"Researcher","foaf:name":[{"@value":"Yoshihiro Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043579892743","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro 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