{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137043601668992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1136/hrt.2007.125898"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1136/hrt.2007.125898"}}],"dc:title":[{"@value":"Cooled ablation reduces pulmonary vein isolation time: results of a prospective randomised trial"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n                  <jats:title>Background:</jats:title>\n                  <jats:p>Currently, selection of the ablation catheter for pulmonary vein (PV) isolation is a matter of choice.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:</jats:title>\n                  <jats:p>To evaluate the efficiency of cooled ablation for PV isolation.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:</jats:title>\n                  <jats:p>A prospective randomised trial was carried out comparing the time required to disconnect each targeted PV using cooled ablation (open irrigation at 15 ml/min, group A) or standard temperature-controlled 4 mm tip catheter ablation (group B). The ablation parameter limit settings were 45°C, 35 (5) W in group A, and 55°C, 35 (5) W in group B.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results:</jats:title>\n                  <jats:p>Thirty-six patients referred for a first atrial fibrillation (AF) ablation procedure were randomised to group A or group B (18 patients in each group). There were no significant differences in baseline characteristics between the groups. Bidirectional block was achieved in 61/61 PVs from group A (100%) and 59/61 PVs from group B (97%); p = NS. Time to PV disconnection was significantly shorter in group A than in group B (median (25th–75th centiles) 14 (5–28) min vs 19 (14–32) min, respectively; p<jats:italic> = </jats:italic>0.003). Five asymptomatic PV stenoses were identified by MRI, all in group B (p = 0.05). After 1-year minimum follow-up, AF recurrences were less frequently documented in patients treated with cooled ablation (6% vs 33%; p = 0.05).</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:</jats:title>\n                  <jats:p>Cooled ablation is more efficient than standard ablation in achieving PV isolation. Results obtained from this study also suggest a potential benefit of clinical efficacy and safety from cooled ablation, which should be further evaluated in larger clinical trials.</jats:p>\n               </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380025030461465216","@type":"Researcher","foaf:name":[{"@value":"N Pérez-Castellano"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043601668992","@type":"Researcher","foaf:name":[{"@value":"J Villacastin"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043601668864","@type":"Researcher","foaf:name":[{"@value":"J Salinas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043601668996","@type":"Researcher","foaf:name":[{"@value":"J Moreno"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043601668993","@type":"Researcher","foaf:name":[{"@value":"M Doblado"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043601668994","@type":"Researcher","foaf:name":[{"@value":"E Ruiz"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043601668997","@type":"Researcher","foaf:name":[{"@value":"R Isa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043601668995","@type":"Researcher","foaf:name":[{"@value":"C Macaya"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13556037"},{"@type":"EISSN","@value":"1468201X"}],"prism:publicationName":[{"@value":"Heart"}],"dc:publisher":[{"@value":"BMJ"}],"prism:publicationDate":"2007-12-10","prism:volume":"95","prism:number":"3","prism:startingPage":"203","prism:endingPage":"209"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1136/hrt.2007.125898"}],"createdAt":"2007-12-10","modifiedAt":"2025-10-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001205101771136","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Risks and Benefits of an Open Irrigation Tip Catheter in Intensive Radiofrequency Catheter Ablation in Patients With Non-Paroxysmal Atrial Fibrillation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1136/hrt.2007.125898"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-09-0703_references_DOI_QfV3mdKgImkgqCB7UUVRD9Hfrvn"}]}