{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137043640710784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/np034007g"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/np034007g"}},{"identifier":{"@type":"PMID","@value":"15568779"}},{"identifier":{"@type":"NAID","@value":"30011036713"}}],"dc:title":[{"@value":"Biotransformation of Nobiletin by <i>Aspergillus </i><i>n</i><i>iger </i>and the Antimutagenic Activity of a Metabolite, 4‘-Hydroxy-5,6,7,8,3‘-pentamethoxyflavone"}],"description":[{"notation":[{"@value":"Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137043640710784","@type":"Researcher","foaf:name":[{"@value":"Yoshiharu Okuno"}],"jpcoar:affiliationName":[{"@value":"Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043640710785","@type":"Researcher","foaf:name":[{"@value":"Mitsuo Miyazawa"}],"jpcoar:affiliationName":[{"@value":"Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01633864"},{"@type":"EISSN","@value":"15206025"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/01633864"}],"prism:publicationName":[{"@value":"Journal of Natural Products"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2004-10-28","prism:volume":"67","prism:number":"11","prism:startingPage":"1876","prism:endingPage":"1878"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/np034007g"}],"createdAt":"2005-08-16","modifiedAt":"2021-10-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Flavonoids","dc:title":"Flavonoids"},{"@id":"https://cir.nii.ac.jp/all?q=Salmonella%20typhimurium","dc:title":"Salmonella typhimurium"},{"@id":"https://cir.nii.ac.jp/all?q=Citrus","dc:title":"Citrus"},{"@id":"https://cir.nii.ac.jp/all?q=Plants,%20Medicinal","dc:title":"Plants, Medicinal"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Structure","dc:title":"Molecular Structure"},{"@id":"https://cir.nii.ac.jp/all?q=Mutagenicity%20Tests","dc:title":"Mutagenicity Tests"},{"@id":"https://cir.nii.ac.jp/all?q=Flavones","dc:title":"Flavones"},{"@id":"https://cir.nii.ac.jp/all?q=Aspergillus%20niger","dc:title":"Aspergillus niger"},{"@id":"https://cir.nii.ac.jp/all?q=Furylfuramide","dc:title":"Furylfuramide"},{"@id":"https://cir.nii.ac.jp/all?q=SOS%20Response,%20Genetics","dc:title":"SOS Response, Genetics"},{"@id":"https://cir.nii.ac.jp/all?q=Biotransformation","dc:title":"Biotransformation"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285706435557248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4′-demethylnobiletin prevents MK801-induced memory impairment"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679145032832","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biotransformation of Isoflavones by the Larvae of the Common Cutworm (Spodoptera litura)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679602332928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative Study on Nobiletin Metabolism with Liver Microsomes from Rats, Guinea Pigs and Hamsters and Rat Cytochrome P450"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317026699648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1021/np034007g"},{"@type":"CIA","@value":"30011036713"},{"@type":"OPENAIRE","@value":"doi_dedup___::d5058e50783dc7b90e38ccaf5cf727f1"},{"@type":"CROSSREF","@value":"10.1007/s11418-017-1091-8_references_DOI_DWAJX4HuEMK9RAKeKBufFEBaJjS"},{"@type":"CROSSREF","@value":"10.1186/s41021-020-00156-0_references_DOI_DWAJX4HuEMK9RAKeKBufFEBaJjS"},{"@type":"CROSSREF","@value":"10.1248/cpb.54.719_references_DOI_DWAJX4HuEMK9RAKeKBufFEBaJjS"},{"@type":"CROSSREF","@value":"10.1248/bpb.30.2317_references_DOI_DWAJX4HuEMK9RAKeKBufFEBaJjS"}]}