{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137043867201792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/anie.201702181"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201702181"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201702181"}}],"dc:title":[{"@value":"Cross‐Regulation of an Artificial Metalloenzyme"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Cross‐regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross‐regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137043867201793","@type":"Researcher","foaf:name":[{"@value":"Yasunori Okamoto"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry University of Basel  Spitalstrasse 51 4056 Basel Switzerland"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043867201792","@type":"Researcher","foaf:name":[{"@value":"Thomas R. Ward"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry University of Basel  Spitalstrasse 51 4056 Basel Switzerland"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14337851"},{"@type":"EISSN","@value":"15213773"}],"prism:publicationName":[{"@value":"Angewandte Chemie International Edition"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2017-05-31","prism:volume":"56","prism:number":"34","prism:startingPage":"10156","prism:endingPage":"10160"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201702181"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201702181"}],"createdAt":"2017-05-09","modifiedAt":"2023-09-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168831790848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intracellular Unnatural Catalysis Enabled by an Artificial Metalloenzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092711540736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Artificial Metalloenzymes: From Selective Chemical Transformations to Biochemical Applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641535400832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic Organic Reactions in Water toward Sustainable Society"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367081136768","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exploring and adapting the molecular selectivity of artificial metalloenzymes"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/anie.201702181"},{"@type":"CROSSREF","@value":"10.1007/978-1-0716-1441-9_17_references_DOI_7QPSVx1kHoMhnJ8wcV3uqB21N05"},{"@type":"CROSSREF","@value":"10.1021/acs.chemrev.7b00417_references_DOI_7QPSVx1kHoMhnJ8wcV3uqB21N05"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20200316_references_DOI_7QPSVx1kHoMhnJ8wcV3uqB21N05"},{"@type":"CROSSREF","@value":"10.3390/molecules25132989_references_DOI_7QPSVx1kHoMhnJ8wcV3uqB21N05"}]}