{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137043875204992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/ilar/ily026"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/ilarjournal/article-pdf/59/3/211/36274695/ily026.pdf"}},{"identifier":{"@type":"PMID","@value":"31197363"}}],"dc:title":[{"@value":"Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>In 1989 ILAR published a list and description of immunodeficient rodents used in research. Since then, advances in understanding of molecular mechanisms; recognition of genetic, epigenetic microbial, and other influences on immunity; and capabilities in manipulating genomes and microbiomes have increased options and opportunities for selecting mice and designing studies to answer important mechanistic and therapeutic questions. Despite numerous scientific breakthroughs that have benefitted from research in mice, there is debate about the relevance and predictive or translational value of research in mice. Reproducibility of results obtained from mice and other research models also is a well-publicized concern. This review summarizes resources to inform the selection and use of immune relevant mouse strains and stocks, aiming to improve the utility, validity, and reproducibility of research in mice. Immune sufficient genetic variations, immune relevant spontaneous mutations, immunodeficient and autoimmune phenotypes, and selected induced conditions are emphasized.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137043875204993","@type":"Researcher","foaf:name":[{"@value":"Enrico Radaelli"}],"jpcoar:affiliationName":[{"@value":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043875205120","@type":"Researcher","foaf:name":[{"@value":"Sara F Santagostino"}],"jpcoar:affiliationName":[{"@value":"Department of Safety Assessment, Genentech, Inc., South San Francisco, California"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043875204992","@type":"Researcher","foaf:name":[{"@value":"Rani S Sellers"}],"jpcoar:affiliationName":[{"@value":"Pfizer, Inc, Pearl River, New York"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137043875205121","@type":"Researcher","foaf:name":[{"@value":"Cory F Brayton"}],"jpcoar:affiliationName":[{"@value":"Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10842020"},{"@type":"EISSN","@value":"19306180"}],"prism:publicationName":[{"@value":"ILAR Journal"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2018","prism:volume":"59","prism:number":"3","prism:startingPage":"211","prism:endingPage":"246"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"],"url":[{"@id":"http://academic.oup.com/ilarjournal/article-pdf/59/3/211/36274695/ily026.pdf"}],"createdAt":"2019-01-21","modifiedAt":"2024-07-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Translational%20Research,%20Biomedical","dc:title":"Translational Research, Biomedical"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Immune%20System","dc:title":"Immune System"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Variation","dc:title":"Genetic Variation"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390291115046271104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Eliminating murine norovirus, <i>Helicobacter hepaticus</i>, and intestinal protozoa by embryo transfer for an entire mouse barrier facility"}]},{"@id":"https://cir.nii.ac.jp/crid/1880020692641660160","@type":"Dataset","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Additional file 8: of Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations"}]},{"@id":"https://cir.nii.ac.jp/crid/1884242817279748608","@type":"Dataset","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/ilar/ily026"},{"@type":"OPENAIRE","@value":"doi_dedup___::e758bfe20601ad2109d76c24f706a010"},{"@type":"CROSSREF","@value":"10.1538/expanim.21-0026_references_DOI_MPMpZcekRJZqJ7vYH5T3AQHoWNA"}]}