{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044087728256.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/ajpregu.1984.246.5.r776"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/ajpregu.1984.246.5.R776"}}],"dc:title":[{"@value":"Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Food and water intake of free-feeding rats with indwelling intraperitoneal catheters connected to infusion pumps was continuously monitored and recorded by a microcomputer-based data acquisition system. Initially, at the start of every spontaneous meal for 4 days, each rat was infused with 0.27 ml of physiological saline. Saline infusion did not affect any feeding or drinking patterns, and the rate of weight gain remained unchanged. For 6 subsequent days, the octapeptide of cholecystokinin (CCK-8, 1.1 micrograms/meal) dissolved in physiological saline was infused at the onset of each meal. CCK-8 infusion caused a dramatic shift of patterns of food intake. Average meal size was reduced by at least 44%, whereas daily meal number increased by 162% or more for all 6 days of CCK-8 infusion. Total daily food intake recovered to predrug levels by the 4th day of CCK-8 infusion, primarily due to increased feeding frequency. Average body weight dropped by 12.4 g on the 1st day of CCK infusion, but over the following 5 days the growth rate was not different from the base-line predrug rate. With discontinuation of CCK-8 infusion all meal patterns returned rapidly to normal and body weight immediately recovered. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044087728258","@type":"Researcher","foaf:name":[{"@value":"D. B. West"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044087728256","@type":"Researcher","foaf:name":[{"@value":"D. Fey"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044087728257","@type":"Researcher","foaf:name":[{"@value":"S. C. Woods"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03636119"},{"@type":"EISSN","@value":"15221490"}],"prism:publicationName":[{"@value":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"1984-05-01","prism:volume":"246","prism:number":"5","prism:startingPage":"R776","prism:endingPage":"R787"},"reviewed":"false","url":[{"@id":"https://www.physiology.org/doi/pdf/10.1152/ajpregu.1984.246.5.R776"}],"createdAt":"2017-12-24","modifiedAt":"2019-09-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567186273807872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206298822656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of gut hormones and the hypothalamus in appetite regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206478534656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Soybean .BETA.-Conglycinin Bromelain Hydrolysate Stimulates Cholecystokinin Secretion by Enteroendocrine STC-1 Cells to Suppress the Appetite of Rats under Meal-Feeding Conditions"},{"@value":"Soybean β-conglycinin bromelain hydrolysate stimulates cholecystokinin secretion by enteroendocrine STC-1 cells to suppress the appetite of rats under meal-feeding conditions"},{"@language":"ja-Kana","@value":"Soybean v conglycinin bromelain hydrolysate stimulates cholecystokinin secretion by enteroendocrine STC 1 cells to suppress the appetite of rats under meal feeding conditions"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1152/ajpregu.1984.246.5.r776"},{"@type":"CROSSREF","@value":"10.1507/endocrj.k10e-077_references_DOI_SMyWAyFsrtTADwRBoDdL29QPlj7"},{"@type":"CROSSREF","@value":"10.1271/bbb.100765_references_DOI_SMyWAyFsrtTADwRBoDdL29QPlj7"},{"@type":"CROSSREF","@value":"10.1152/ajpendo.00664.2013_references_DOI_SMyWAyFsrtTADwRBoDdL29QPlj7"}]}