{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044103670144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/mmi.13272"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmmi.13272"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.13272"}}],"dc:title":[{"@value":"<i>Escherichia coli</i> ClbS is a colibactin resistance protein"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>The genomic <jats:italic>pks</jats:italic> island codes for the biosynthetic machinery that produces colibactin, a peptide‐polyketide metabolite. Colibactin is a genotoxin that contributes to the virulence of extra‐intestinal pathogenic <jats:styled-content style=\"fixed-case\"><jats:italic>E</jats:italic></jats:styled-content><jats:italic>scherichia coli</jats:italic> and promotes colorectal cancer. In this work, we examined whether the <jats:italic>pks</jats:italic>‐encoded <jats:italic>clbS</jats:italic> gene of unknown function could participate in the self‐protection of <jats:styled-content style=\"fixed-case\"><jats:italic>E</jats:italic></jats:styled-content><jats:italic>. coli</jats:italic>‐producing colibactin. A <jats:italic>clb</jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>S</jats:italic></jats:styled-content> mutant was not impaired in the ability to inflict <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content> damage in <jats:styled-content style=\"fixed-case\">HeL</jats:styled-content>a cells, but the bacteria activated the <jats:styled-content style=\"fixed-case\">SOS</jats:styled-content> response and ceased to replicate. This autotoxicity phenotype was markedly enhanced in a <jats:italic>clb</jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>S</jats:italic></jats:styled-content> <jats:italic>uvr</jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>B</jats:italic></jats:styled-content> double mutant inactivated for <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content> repair by nucleotide excision but was suppressed in a <jats:italic>clb</jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>S</jats:italic></jats:styled-content> <jats:italic>clb</jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>A</jats:italic></jats:styled-content> double mutant unable to produce colibactin. In addition, ectopic expression of <jats:italic>clb</jats:italic><jats:styled-content style=\"fixed-case\"><jats:italic>S</jats:italic></jats:styled-content> protected infected <jats:styled-content style=\"fixed-case\">HeL</jats:styled-content>a cells from colibactin. Thus, <jats:styled-content style=\"fixed-case\">ClbS</jats:styled-content> is a resistance protein blocking the genotoxicity of colibactin both in the procaryotic and the eucaryotic cells.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861293619599105","@type":"Researcher","foaf:name":[{"@value":"Nadège Bossuet‐Greif"}],"jpcoar:affiliationName":[{"@value":"INRA, USC 1360  Toulouse France"},{"@value":"Inserm, UMR 1043  Toulouse France"},{"@value":"CNRS, UMR 5282  Toulouse France"},{"@value":"Université de Toulouse, UPS  Toulouse France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044103670148","@type":"Researcher","foaf:name":[{"@value":"Damien Dubois"}],"jpcoar:affiliationName":[{"@value":"INRA, USC 1360  Toulouse France"},{"@value":"Inserm, UMR 1043  Toulouse France"},{"@value":"CNRS, UMR 5282  Toulouse France"},{"@value":"Université de Toulouse, UPS  Toulouse France"},{"@value":"CHU Toulouse, Service de bactériologie‐Hygiène  Toulouse France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044103670145","@type":"Researcher","foaf:name":[{"@value":"Claude Petit"}],"jpcoar:affiliationName":[{"@value":"INRA, USC 1360  Toulouse France"},{"@value":"Inserm, UMR 1043  Toulouse France"},{"@value":"CNRS, UMR 5282  Toulouse France"},{"@value":"Université de Toulouse, UPS  Toulouse France"},{"@value":"INP‐ENVT ESC  Toulouse France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044103670151","@type":"Researcher","foaf:name":[{"@value":"Sophie Tronnet"}],"jpcoar:affiliationName":[{"@value":"INRA, USC 1360  Toulouse France"},{"@value":"Inserm, UMR 1043  Toulouse France"},{"@value":"CNRS, UMR 5282  Toulouse France"},{"@value":"Université de Toulouse, UPS  Toulouse France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044103670150","@type":"Researcher","foaf:name":[{"@value":"Patricia Martin"}],"jpcoar:affiliationName":[{"@value":"INRA, USC 1360  Toulouse France"},{"@value":"Inserm, UMR 1043  Toulouse France"},{"@value":"CNRS, UMR 5282  Toulouse France"},{"@value":"Université de Toulouse, UPS  Toulouse France"},{"@value":"CHU Toulouse, Service de bactériologie‐Hygiène  Toulouse France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044103670147","@type":"Researcher","foaf:name":[{"@value":"Richard Bonnet"}],"jpcoar:affiliationName":[{"@value":"Université d'Auvergne, Inserm UMR 1071, INRA USC 2018  Clermont‐Ferrand France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044103670144","@type":"Researcher","foaf:name":[{"@value":"Eric Oswald"}],"jpcoar:affiliationName":[{"@value":"INRA, USC 1360  Toulouse France"},{"@value":"Inserm, UMR 1043  Toulouse France"},{"@value":"CNRS, UMR 5282  Toulouse France"},{"@value":"Université de Toulouse, UPS  Toulouse France"},{"@value":"CHU Toulouse, Service de bactériologie‐Hygiène  Toulouse France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861293619599104","@type":"Researcher","foaf:name":[{"@value":"Jean‐Philippe Nougayrède"}],"jpcoar:affiliationName":[{"@value":"INRA, USC 1360  Toulouse France"},{"@value":"Inserm, UMR 1043  Toulouse France"},{"@value":"CNRS, UMR 5282  Toulouse France"},{"@value":"Université de Toulouse, UPS  Toulouse France"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0950382X"},{"@type":"EISSN","@value":"13652958"}],"prism:publicationName":[{"@value":"Molecular Microbiology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-12","prism:volume":"99","prism:number":"5","prism:startingPage":"897","prism:endingPage":"908"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmmi.13272"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.13272"}],"createdAt":"2015-11-12","modifiedAt":"2023-10-01","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050855676748719360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of Escherichia coli strains obtained from the Japan Collection of Microorganisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865723139584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mucosal adjuvanticity and mucosal booster effect of colibactin-depleted probiotic\n            <i>Escherichia coli</i>\n            membrane vesicles"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/mmi.13272"},{"@type":"CROSSREF","@value":"10.1186/s41021-020-00149-z_references_DOI_QG9ZOLNjOqp4R4952K2uAPGYEM4"},{"@type":"CROSSREF","@value":"10.1080/21645515.2024.2337987_references_DOI_QG9ZOLNjOqp4R4952K2uAPGYEM4"}]}