{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044215115648.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/s12943-020-01157-x"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1186/s12943-020-01157-x.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1186/s12943-020-01157-x/fulltext.html"}}],"dc:title":[{"@value":"The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implications on cell death linked to cardiomyopathy, tumorigenesis, and cerebral hemorrhage to name a few. Here we summarize current literature on ferroptosis, including organelle dysfunction, signaling transduction pathways, metabolic reprogramming and epigenetic regulators in cancer progression. With regard to organelles, mitochondria-induced cysteine starvation, endoplasmic reticulum-related oxidative stress, lysosome dysfunction and golgi stress-related lipid peroxidation all contribute to induction of ferroptosis. Understanding the underlying mechanism in ferroptosis could provide insight into the treatment of various intractable diseases including cancers.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044215115652","@type":"Researcher","foaf:name":[{"@value":"Yuqing Wu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044215115653","@type":"Researcher","foaf:name":[{"@value":"Siwei Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044215115649","@type":"Researcher","foaf:name":[{"@value":"Xiaoxiao Gong"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044215115654","@type":"Researcher","foaf:name":[{"@value":"Samantha Tam"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044215115651","@type":"Researcher","foaf:name":[{"@value":"Desheng Xiao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044215115650","@type":"Researcher","foaf:name":[{"@value":"Shuang Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044215115648","@type":"Researcher","foaf:name":[{"@value":"Yongguang Tao"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14764598"}],"prism:publicationName":[{"@value":"Molecular Cancer"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2020-02-27","prism:volume":"19","prism:number":"1","prism:startingPage":"39"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1186/s12943-020-01157-x.pdf"},{"@id":"http://link.springer.com/article/10.1186/s12943-020-01157-x/fulltext.html"}],"createdAt":"2020-02-27","modifiedAt":"2023-09-27","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168870652928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567380975104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High-Throughput Screening for the Discovery of Iron Homeostasis Modulators Using an Extremely Sensitive Fluorescent Probe"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704772667392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894409730176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1186/s12943-020-01157-x"},{"@type":"CROSSREF","@value":"10.3390/cells11030394_references_DOI_9sbMhQIFNEnQlAXyP4HIPQsnqjQ"},{"@type":"CROSSREF","@value":"10.1021/acssensors.0c01445_references_DOI_9sbMhQIFNEnQlAXyP4HIPQsnqjQ"},{"@type":"CROSSREF","@value":"10.1016/j.redox.2021.101989_references_DOI_9sbMhQIFNEnQlAXyP4HIPQsnqjQ"},{"@type":"CROSSREF","@value":"10.1002/cam4.5243_references_DOI_9sbMhQIFNEnQlAXyP4HIPQsnqjQ"}]}