{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044291103360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1193225"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1193225"}}],"dc:title":[{"@value":"Spiroindolones, a Potent Compound Class for the Treatment of Malaria"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Antimalarial Drug Candidate</jats:title>\n                  <jats:p>\n                    Spiroindolones were discovered as promising antimalarial drug candidates through a high-throughput screening approach that should be applicable to a range of neglected infectious diseases.\n                    <jats:bold>\n                      Rottmann\n                      <jats:italic>et al.</jats:italic>\n                    </jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"1175\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126/science.1193225\">1175</jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"5996\" page=\"1153\" related-article-type=\"in-this-issue\" vol=\"329\" xlink:href=\"10.1126/science.1194923\">Wells</jats:related-article>\n                    </jats:bold>\n                    ) present the preclinical profile for an optimized spiroindolone drug candidate, NITD609. They obtained evidence for a decrease in drug sensitivity in strains of the malaria parasite\n                    <jats:italic>Plasmodium falciparum</jats:italic>\n                    bearing amino acid mutations in the P-type ATPase, indicating possible mechanisms of action and/or resistance.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044291103364","@type":"Researcher","foaf:name":[{"@value":"Matthias Rottmann"}],"jpcoar:affiliationName":[{"@value":"Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland."},{"@value":"University of Basel, CH-4003 Basel, Switzerland."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103498","@type":"Researcher","foaf:name":[{"@value":"Case McNamara"}],"jpcoar:affiliationName":[{"@value":"Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103493","@type":"Researcher","foaf:name":[{"@value":"Bryan K. S. Yeung"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103490","@type":"Researcher","foaf:name":[{"@value":"Marcus C. S. Lee"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103495","@type":"Researcher","foaf:name":[{"@value":"Bin Zou"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103367","@type":"Researcher","foaf:name":[{"@value":"Bruce Russell"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Biopolis, 138648, Singapore."},{"@value":"Department of Microbiology, National University of Singapore, 117597, Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103362","@type":"Researcher","foaf:name":[{"@value":"Patrick Seitz"}],"jpcoar:affiliationName":[{"@value":"Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland."},{"@value":"University of Basel, CH-4003 Basel, Switzerland."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103372","@type":"Researcher","foaf:name":[{"@value":"David M. Plouffe"}],"jpcoar:affiliationName":[{"@value":"Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103370","@type":"Researcher","foaf:name":[{"@value":"Neekesh V. Dharia"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103494","@type":"Researcher","foaf:name":[{"@value":"Jocelyn Tan"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103363","@type":"Researcher","foaf:name":[{"@value":"Steven B. Cohen"}],"jpcoar:affiliationName":[{"@value":"Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103375","@type":"Researcher","foaf:name":[{"@value":"Kathryn R. Spencer"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103360","@type":"Researcher","foaf:name":[{"@value":"Gonzalo E. González-Páez"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103373","@type":"Researcher","foaf:name":[{"@value":"Suresh B. Lakshminarayana"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103361","@type":"Researcher","foaf:name":[{"@value":"Anne Goh"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103488","@type":"Researcher","foaf:name":[{"@value":"Rossarin Suwanarusk"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Biopolis, 138648, Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103492","@type":"Researcher","foaf:name":[{"@value":"Timothy Jegla"}],"jpcoar:affiliationName":[{"@value":"Department of Biology and Huck Institute of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103491","@type":"Researcher","foaf:name":[{"@value":"Esther K. Schmitt"}],"jpcoar:affiliationName":[{"@value":"Natural Products Unit, Novartis Pharma AG, CH-4002 Basel, Switzerland."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103369","@type":"Researcher","foaf:name":[{"@value":"Hans-Peter Beck"}],"jpcoar:affiliationName":[{"@value":"Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland."},{"@value":"University of Basel, CH-4003 Basel, Switzerland."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103374","@type":"Researcher","foaf:name":[{"@value":"Reto Brun"}],"jpcoar:affiliationName":[{"@value":"Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland."},{"@value":"University of Basel, CH-4003 Basel, Switzerland."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103496","@type":"Researcher","foaf:name":[{"@value":"Francois Nosten"}],"jpcoar:affiliationName":[{"@value":"Shoklo Malaria Research Unit, Mae Sot, Tak 63110, Thailand."},{"@value":"Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"@value":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103371","@type":"Researcher","foaf:name":[{"@value":"Laurent Renia"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Biopolis, 138648, Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103366","@type":"Researcher","foaf:name":[{"@value":"Veronique Dartois"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103365","@type":"Researcher","foaf:name":[{"@value":"Thomas H. Keller"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103368","@type":"Researcher","foaf:name":[{"@value":"David A. Fidock"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA."},{"@value":"Department of Medicine (Division of Infectious Diseases), Columbia University Medical Center, New York, NY 10032, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103489","@type":"Researcher","foaf:name":[{"@value":"Elizabeth A. Winzeler"}],"jpcoar:affiliationName":[{"@value":"Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA."},{"@value":"Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044291103497","@type":"Researcher","foaf:name":[{"@value":"Thierry T. Diagana"}],"jpcoar:affiliationName":[{"@value":"Novartis Institute for Tropical Diseases, 138670 Singapore."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2010-09-03","prism:volume":"329","prism:number":"5996","prism:startingPage":"1175","prism:endingPage":"1180"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1193225"}],"createdAt":"2010-09-02","modifiedAt":"2024-01-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002214438536960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic Asymmetric Synthesis of Spirooxindoles via Addition of Isothiocyanato Oxindoles to Aldehydes Under Dinuclear Nickel Schiff Base Catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216612747008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233131099904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>N</i>-Heterocycle-Forming Amino/Carboperfluoroalkylations of Aminoalkenes by Using Perfluoro Acid Anhydrides: Mechanistic Studies and Applications Directed Toward Perfluoroalkylated Compound Libraries"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233533836288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239761137152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enantioselective Synthesis of Spirooxindoles via Direct Catalytic Asymmetric Aldol-Type Reaction of Isothiocyanato Oxindoles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239761144576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005518010651392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic Asymmetric Aza-Friedel–Crafts-Type Reaction of Indoles with Isatin-Derived <i>N</i>-Cbz-Ketimines Using a Chiral Bis(Imidazolidine)-Containing NCN-Pincer Palladium Catalyst"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016863415314176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Facile Access to Spirooxindoles by Halogen-mediated Electrochemical Semi-pinacol Rearrangement"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390756010240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Silylacetate-promoted addition reaction of isocyanides to nitrones: effective synthesis of C(1)-carboxamide derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694491385472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706435478784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169058942592","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Simple and Efficient Procedure for the One-pot Three-component Synthesis of Spiro[indoline-3,9′-tetrazolo[5,1-<i>b</i>]quinazoline]-2,8′(5′<i>H</i>)-dione in PEG–H2O Medium"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182007310976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Modular Strategy for the Direct Catalytic Asymmetric α-Amination of Carbonyl Compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183551272960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"An enantioselective organocatalyzed aza-Morita–Baylis–Hillman reaction of isatin-derived ketimines with acrolein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184516249728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Generation of Rodent Malaria Parasites with a High Mutation Rate by Destructing Proofreading Activity of DNA Polymerase δ"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340706538624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vicinal All‐Carbon Quaternary Stereocenter Construction with Trifluoromethyl Groups via Organocatalytic Asymmetric Cascade Michael/Michael Reaction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846639353972096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich‐Type Reaction of Isothiocyanato Oxindoles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641612352000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bis(imidazolidine)pyridine-NiCl<sub>2</sub> Catalyst for Nitro-Mannich Reaction of Isatin-Derived <i>N</i>-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664691174400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic Asymmetric Amination of Oxindoles under Dinuclear Nickel Schiff Base Catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205339333376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enantioselective Reaction Using Palladium Pincer Complexes with <i>C</i><sub>2</sub>-Symmetric Chiral Bis(imidazoline)s"},{"@value":"Enantioselective Reaction Using Palladium Pincer Complexes with C₂-Symmetric Chiral Bis(imidazoline)s"}]},{"@id":"https://cir.nii.ac.jp/crid/1390301396973339008","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthetic Organic Electrolysis Using Catalysts"},{"@language":"ja","@value":"臭化物イオンや電子を触媒として利用した有機電解合成反応"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892096788096","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fluoroalkylation methods for synthesizing versatile building blocks"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317025192576","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Highly diastereoselective synthesis of tetralin-fused spirooxindoles via Lewis acid-catalyzed C(sp3)-H"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.1193225"},{"@type":"CROSSREF","@value":"10.1002/asia.201300251_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1038/srep23454_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20190080_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1016/j.chempr.2016.10.012_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.3987/com-13-s(s)60_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1021/acs.orglett.9b03148_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1021/acs.orglett.5b02300_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.3987/com-11-s(p)66_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1246/cl.220368_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1039/d3ob01777j_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1371/journal.ppat.1005763_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1007/s11418-016-1012-2_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.73.1062_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1246/cl.180275_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1039/c5ob00874c_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1093/dnares/dsu009_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1021/ol501085y_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.82.867_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1002/asia.202300931_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1002/anie.201203005_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.3987/com-14-12941_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1246/cl.140186_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.7b02307_references_DOI_aRH03JEkzpomFk8nX2Ona5W5Ag5"}]}