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We examined membrane permeabilizing action by amphidinol analogues with structural variations in polyhydroxy and polyene moieties. Consequently, the polyene and polyhydroxy moieties turned out to play important roles in binding to lipid bilayer membrane and in forming ion-permeable pore/lesion across membrane, respectively. NMR-constrained modeling experiments have revealed for the fist time that amphidinols in membrane generally take a hairpin configuration, which plausibly accounts for their potent antifungal and other membrane permeabilizing activities."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044312302978","@type":"Researcher","foaf:name":[{"@value":"Toshihiro Houdai"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044312302977","@type":"Researcher","foaf:name":[{"@value":"Shigeru Matsuoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044312302979","@type":"Researcher","foaf:name":[{"@value":"Nagy Morsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044312302981","@type":"Researcher","foaf:name":[{"@value":"Nobuaki Matsumori"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044312302976","@type":"Researcher","foaf:name":[{"@value":"Masayuki Satake"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044312302980","@type":"Researcher","foaf:name":[{"@value":"Michio 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