{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044443887360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/chem.201303387"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201303387"}},{"identifier":{"@type":"URI","@value":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201303387"}}],"dc:title":[{"@value":"Efficient Copper‐Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen‐Based Nucleophiles"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>A mild, convenient, and step‐economical intramolecular aminotrifluoromethylation of unactivated alkenes with a variety of electronically distinct, nitrogen‐based nucleophiles in the presence of a simple copper salt catalyst, in the absence of extra ligands, is described. Many different nitrogen‐based nucleophiles (e.g., basic primary aliphatic and aromatic amines, sulfonamides, carbamates, and ureas) can be employed in this new aminotrifluoromethylation reaction. The aminotrifluoromethylation process allows straightforward access to diversely substituted CF<jats:sub>3</jats:sub>‐containing pyrrolidines or indolines, in good to excellent yields, through a direct difunctionalization strategy from the respective acyclic starting materials. Mechanistic studies were conducted and a plausible mechanism was proposed.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380016868903834243","@type":"Researcher","foaf:name":[{"@value":"Jin‐Shun Lin"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016868903834242","@type":"Researcher","foaf:name":[{"@value":"Ya‐Ping Xiong"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016868903834240","@type":"Researcher","foaf:name":[{"@value":"Can‐Liang Ma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016868903834244","@type":"Researcher","foaf:name":[{"@value":"Li‐Jiao Zhao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044443887489","@type":"Researcher","foaf:name":[{"@value":"Bin Tan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016868903834241","@type":"Researcher","foaf:name":[{"@value":"Xin‐Yuan Liu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09476539"},{"@type":"EISSN","@value":"15213765"}],"prism:publicationName":[{"@value":"Chemistry – A European Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-12-20","prism:volume":"20","prism:number":"5","prism:startingPage":"1332","prism:endingPage":"1340"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201303387"},{"@id":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201303387"}],"createdAt":"2013-12-20","modifiedAt":"2025-10-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233131099904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>N</i>-Heterocycle-Forming Amino/Carboperfluoroalkylations of Aminoalkenes by Using Perfluoro Acid Anhydrides: Mechanistic Studies and Applications Directed Toward Perfluoroalkylated Compound Libraries"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705587639552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution and Future of Hetero‐ and Hydro‐Trifluoromethylations of Unsaturated C−C Bonds"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285300161209344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fluorofunctionalizations of C–C Multiple Bonds  and C–H Bonds"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892096788096","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fluoroalkylation methods for synthesizing versatile building blocks"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/chem.201303387"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20190080_references_DOI_NlCVpZwoqRK7CbeVaNkBsr0SL32"},{"@type":"CROSSREF","@value":"10.1248/cpb.c19-00856_references_DOI_NlCVpZwoqRK7CbeVaNkBsr0SL32"},{"@type":"CROSSREF","@value":"10.1002/adsc.202201268_references_DOI_NlCVpZwoqRK7CbeVaNkBsr0SL32"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.7b02307_references_DOI_NlCVpZwoqRK7CbeVaNkBsr0SL32"}]}