{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044456295296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ijpharm.2007.10.008"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S037851730700837X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S037851730700837X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"18037251"}}],"dc:title":[{"@value":"Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug"}],"description":[{"notation":[{"@value":"Mean plasma concentration-time profile of griseofulvin, a BCS class II drug, orally administered as powders into rats, was predicted based on GITA model. However, it was very difficult to predict the individual plasma profile because of large inter-individual difference. As the absorption of griseofulvin would be rate-limited by the dissolution process, we tried to analyze the in vivo dissolution kinetics of griseofulvin by focusing on gastric emptying and intestinal transit as physiological factors influencing the in vivo dissolution kinetics. After oral administration of griseofulvin, theophylline and sulfasalazine into rats, gastric emptying and intestinal transit were simultaneously estimated by analyzing the absorption kinetics of theophylline and observing the appearance of sulfapyridine in plasma, respectively. Gastric emptying kinetics was not significantly correlated with absorption or dissolution behavior of griseofulvin. On the other hand, the cecum-arriving time reflecting the intestinal transit was significantly correlated with both AUC and total dissolved amount of griseofulvin. T(max) of griseofulvin also increased with the increase of cecum-arriving time. These results clearly indicate that the longer residence time could lead to the higher dissolution and absorption of griseofulvin and that the variance of intestinal transit could be responsible for the inter-individual difference of the in vivo absorption behavior."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044456295297","@type":"Researcher","foaf:name":[{"@value":"Yoshitsugu Fujioka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044456295296","@type":"Researcher","foaf:name":[{"@value":"Yukiko Metsugi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044456295298","@type":"Researcher","foaf:name":[{"@value":"Ken-ichi Ogawara"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044456295299","@type":"Researcher","foaf:name":[{"@value":"Kazutaka Higaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044456295424","@type":"Researcher","foaf:name":[{"@value":"Toshikiro Kimura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03785173"}],"prism:publicationName":[{"@value":"International Journal of Pharmaceutics"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2008-03","prism:volume":"352","prism:number":"1-2","prism:startingPage":"36","prism:endingPage":"43"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S037851730700837X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S037851730700837X?httpAccept=text/plain"}],"createdAt":"2007-11-28","modifiedAt":"2025-10-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Antifungal%20Agents","dc:title":"Antifungal Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Administration,%20Oral","dc:title":"Administration, Oral"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Biological","dc:title":"Models, Biological"},{"@id":"https://cir.nii.ac.jp/all?q=Griseofulvin","dc:title":"Griseofulvin"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Gastric%20Emptying","dc:title":"Gastric Emptying"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Absorption","dc:title":"Intestinal Absorption"},{"@id":"https://cir.nii.ac.jp/all?q=Solubility","dc:title":"Solubility"},{"@id":"https://cir.nii.ac.jp/all?q=Sulfapyridine","dc:title":"Sulfapyridine"},{"@id":"https://cir.nii.ac.jp/all?q=Theophylline","dc:title":"Theophylline"},{"@id":"https://cir.nii.ac.jp/all?q=Injections,%20Intravenous","dc:title":"Injections, Intravenous"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Powders","dc:title":"Powders"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Gastrointestinal%20Transit","dc:title":"Gastrointestinal Transit"},{"@id":"https://cir.nii.ac.jp/all?q=Cecum","dc:title":"Cecum"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050573560444566144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pharmacokinetic analysis of new synthetic antimalarial N-251"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656349055744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705573464960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of Excessive Serotonin on Pharmacokinetics of Cephalexin after Oral Administration: Studies with Serotonin-Excessive Model Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681105932544","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"薬物吸収制御因子の解析と吸収改善"},{"@language":"en","@value":"Analysis of Factors Governing Drug Absorption and Their Improvement"},{"@language":"ja-Kana","@value":"ヤクブツ キュウシュウ セイギョ インシ ノ カイセキ ト キュウシュウ カイゼン"},{"@value":"ChemInform Abstract: Analysis of Factors Governing Drug Absorption and Their Improvement"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.ijpharm.2007.10.008"},{"@type":"OPENAIRE","@value":"doi_dedup___::53e6e2dc634cc88bd92bc442d3aade0a"},{"@type":"CROSSREF","@value":"10.1248/yakushi.129.911_references_DOI_M33w3ygA18SYpW4hGRrbewPHOWy"},{"@type":"CROSSREF","@value":"10.1186/s41182-019-0167-4_references_DOI_M33w3ygA18SYpW4hGRrbewPHOWy"},{"@type":"CROSSREF","@value":"10.1007/s11095-015-1646-x_references_DOI_M33w3ygA18SYpW4hGRrbewPHOWy"},{"@type":"CROSSREF","@value":"10.1007/s11095-022-03325-8_references_DOI_M33w3ygA18SYpW4hGRrbewPHOWy"}]}