{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044483032064.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.15252/msb.20156297"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/msb.20156297"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.15252/msb.20156297"}},{"identifier":{"@type":"URI","@value":"https://www.embopress.org/doi/pdf/10.15252/msb.20156297"}},{"identifier":{"@type":"PMID","@value":"28951502"}},{"identifier":{"@type":"HANDLE","@value":"11858/00-001M-0000-002E-85AF-1"}},{"identifier":{"@type":"HANDLE","@value":"11858/00-001M-0000-002E-85AD-5"}}],"dc:title":[{"@value":"Revisiting biomarker discovery by plasma proteomics"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (\n                    <jats:styled-content style=\"fixed-case\">MS</jats:styled-content>\n                    )‐based proteomics has become a powerful technology in biological research and it is now poised to allow the characterization of the plasma proteome in great depth. Previous “triangular strategies” aimed at discovering single biomarker candidates in small cohorts, followed by classical immunoassays in much larger validation cohorts. We propose a “rectangular” plasma proteome profiling strategy, in which the proteome patterns of large cohorts are correlated with their phenotypes in health and disease. Translating such concepts into clinical practice will require restructuring several aspects of diagnostic decision‐making, and we discuss some first steps in this direction.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044483032192","@type":"Researcher","foaf:name":[{"@value":"Philipp E Geyer"}],"jpcoar:affiliationName":[{"@value":"Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany"},{"@value":"Faculty of Health Sciences NNF Center for Protein Research University of Copenhagen Copenhagen Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044483032064","@type":"Researcher","foaf:name":[{"@value":"Lesca M Holdt"}],"jpcoar:affiliationName":[{"@value":"Institute of Laboratory Medicine University Hospital LMU Munich Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044483032065","@type":"Researcher","foaf:name":[{"@value":"Daniel Teupser"}],"jpcoar:affiliationName":[{"@value":"Institute of Laboratory Medicine University Hospital LMU Munich Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044483032066","@type":"Researcher","foaf:name":[{"@value":"Matthias Mann"}],"jpcoar:affiliationName":[{"@value":"Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany"},{"@value":"Faculty of Health Sciences NNF Center for Protein Research University of Copenhagen Copenhagen Denmark"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"17444292"},{"@type":"EISSN","@value":"17444292"}],"prism:publicationName":[{"@value":"Molecular Systems Biology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2017-09","prism:volume":"13","prism:number":"9","prism:startingPage":"942"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/msb.20156297"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.15252/msb.20156297"},{"@id":"https://www.embopress.org/doi/pdf/10.15252/msb.20156297"}],"createdAt":"2017-09-26","modifiedAt":"2025-12-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Proteomics","dc:title":"Proteomics"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine%20(General)","dc:title":"Medicine (General)"},{"@id":"https://cir.nii.ac.jp/all?q=Proteome","dc:title":"Proteome"},{"@id":"https://cir.nii.ac.jp/all?q=QH301-705.5","dc:title":"QH301-705.5"},{"@id":"https://cir.nii.ac.jp/all?q=610","dc:title":"610"},{"@id":"https://cir.nii.ac.jp/all?q=diagnostic","dc:title":"diagnostic"},{"@id":"https://cir.nii.ac.jp/all?q=Reviews","dc:title":"Reviews"},{"@id":"https://cir.nii.ac.jp/all?q=Review","dc:title":"Review"},{"@id":"https://cir.nii.ac.jp/all?q=Mass%20Spectrometry","dc:title":"Mass Spectrometry"},{"@id":"https://cir.nii.ac.jp/all?q=R5-920","dc:title":"R5-920"},{"@id":"https://cir.nii.ac.jp/all?q=Journal%20Article","dc:title":"Journal Article"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=systems%20medicine","dc:title":"systems medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Biology%20(General)","dc:title":"Biology (General)"},{"@id":"https://cir.nii.ac.jp/all?q=mass%20spectrometry","dc:title":"mass spectrometry"},{"@id":"https://cir.nii.ac.jp/all?q=plasma%20proteomics","dc:title":"plasma proteomics"},{"@id":"https://cir.nii.ac.jp/all?q=biomarkers","dc:title":"biomarkers"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Proteins","dc:title":"Blood Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360005519185474304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mass spectrometry for the identification and analysis of highly complex glycosylation of therapeutic or pathogenic proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390760090368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proteome Analysis of Serum Purified Using Solanum tuberosum and Lycopersicon 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