{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044489293568.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s10147-018-1375-3"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s10147-018-1375-3/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s10147-018-1375-3.pdf"}},{"identifier":{"@type":"PMID","@value":"30515675"}}],"dc:title":[{"@value":"Next-generation sequencing-based clinical sequencing: toward precision medicine in solid tumors"}],"description":[{"notation":[{"@value":"Numerous technical and functional advances in next-generation sequencing (NGS) have led to the adoption of this technique in conventional clinical practice. Recently, large-scale genomic research and NGS technological innovation have revealed many more details of somatic and germline mutations in solid tumors. This development is allowing for the classification of tumor type sub-categories based on genetic alterations in solid tumors, and based on this information, new drugs and targeted therapies are being administered to patients. This has largely been facilitated by gene panel testing, which allows for a better understanding of the genetic basis for an individual's response to therapy. NGS-based comprehensive gene panel testing is a clinically useful approach to investigate genomic mechanisms, including therapy-related signaling pathways, microsatellite instability, hypermutated phenotypes, and tumor mutation burden. In this review, we describe the concept of precision medicine in solid tumors using NGS-based comprehensive gene panel testing, as well as the importance of quality control of tissue sample handling in routine NGS-based genomic testing, and we discuss issues for the future adoption of this technique in Japan."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044489293442","@type":"Researcher","foaf:name":[{"@value":"Toshifumi Wakai"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044489293441","@type":"Researcher","foaf:name":[{"@value":"Pankaj Prasoon"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044489293568","@type":"Researcher","foaf:name":[{"@value":"Yuki Hirose"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044489293569","@type":"Researcher","foaf:name":[{"@value":"Yoshifumi Shimada"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044489293440","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ichikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044489293570","@type":"Researcher","foaf:name":[{"@value":"Masayuki Nagahashi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13419625"},{"@type":"EISSN","@value":"14377772"}],"prism:publicationName":[{"@value":"International Journal of Clinical Oncology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2018-12-04","prism:volume":"24","prism:number":"2","prism:startingPage":"115","prism:endingPage":"122"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/article/10.1007/s10147-018-1375-3/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s10147-018-1375-3.pdf"}],"createdAt":"2018-12-04","modifiedAt":"2019-12-04","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers,%20Tumor","dc:title":"Biomarkers, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=High-Throughput%20Nucleotide%20Sequencing","dc:title":"High-Throughput Nucleotide Sequencing"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Precision%20Medicine","dc:title":"Precision Medicine"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050004225379264512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Current status of treatment with immune checkpoint inhibitors for gastrointestinal, hepatobiliary, and pancreatic cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1050565162619658368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341820526080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"YRNA and tRNA fragments can differentiate benign from malignant canine mammary gland tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131421850083968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Successful Clinical Sequencing by Molecular Tumor Board in an Elderly Patient With Refractory Sézary Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1390850788650904448","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Value of Liquid-based cytology for Companion Diagnostics and Roles of Cytologic Diagnostics on Precision Medicine"},{"@language":"ja","@value":"液状化細胞診検体を用いたコンパニオン診断の試み"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307417117550208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Preparation of the standard cell lines for reference mutations in cancer gene-panels by genome editing in HEK 293 T/17 cells"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s10147-018-1375-3"},{"@type":"OPENAIRE","@value":"doi_dedup___::2f222663c5ee19067cc9b3038d3b6c4b"},{"@type":"CROSSREF","@value":"10.5795/jjscc.60.75_references_DOI_YwqG2SoEWX9sWa9fCRtMywPNg3f"},{"@type":"CROSSREF","@value":"10.1177/1756284820948773_references_DOI_YwqG2SoEWX9sWa9fCRtMywPNg3f"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2023.149336_references_DOI_YwqG2SoEWX9sWa9fCRtMywPNg3f"},{"@type":"CROSSREF","@value":"10.1007/s00535-019-01620-7_references_DOI_YwqG2SoEWX9sWa9fCRtMywPNg3f"},{"@type":"CROSSREF","@value":"10.1186/s41021-020-0147-2_references_DOI_YwqG2SoEWX9sWa9fCRtMywPNg3f"},{"@type":"CROSSREF","@value":"10.1200/po.19.00254_references_DOI_YwqG2SoEWX9sWa9fCRtMywPNg3f"}]}