{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044490608384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/jnr.21625"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjnr.21625"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jnr.21625"}},{"identifier":{"@type":"PMID","@value":"18253944"}}],"dc:title":[{"@value":"Bone marrow‐derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Immune‐mediated inner ear disorder has been well established as a clinical entity; however, the innate immune system of the inner ear is a poorly understood area of research with high clinical and immunological importance. Although the presence of resident tissue macrophages in the inner ear has been suggested, there has been some controversy. In this study, we analyzed the origin of cochlear resident macrophages and the contribution of hematopoietic bone marrow (BM) to the recruitment of macrophages in the cochlea. To visualize the localization of BM‐derived cells, BM chimeric mice were made by transplantation of hematopoietic stem cells, which were genetically labeled with enhanced green fluorescent protein, into lethally irradiated C57BL/6 mice. The distribution and characteristics of BM‐derived cells in the mouse cochlea were studied immunohistochemically. We successfully identified the constitutive presence of tissue resident macrophages in the spiral ligament and spiral ganglion that are derived from BM in larger numbers than previously reported. Moreover, cochlear resident macrophages gradually turn over for several months during steady‐state replacement by BM‐derived cells, and the number of cochlear macrophages immediately increased in response to local surgical stress. The present findings demonstrate the hematopoietic origin of cochlear resident and infiltrating macrophages. Our study provides a novel anatomical and immunological basis for the inner ear and indicates that the cochlear resident macrophages would be a therapeutic target in inner ear disorders. © 2008 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044490608258","@type":"Researcher","foaf:name":[{"@value":"Takayuki Okano"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044490608257","@type":"Researcher","foaf:name":[{"@value":"Takayuki Nakagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044490608384","@type":"Researcher","foaf:name":[{"@value":"Tomoko Kita"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044490608260","@type":"Researcher","foaf:name":[{"@value":"Shinpei Kada"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044490608261","@type":"Researcher","foaf:name":[{"@value":"Momoko Yoshimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044490608256","@type":"Researcher","foaf:name":[{"@value":"Tatsutoshi Nakahata"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044490608259","@type":"Researcher","foaf:name":[{"@value":"Juichi Ito"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03604012"},{"@type":"EISSN","@value":"10974547"}],"prism:publicationName":[{"@value":"Journal of Neuroscience Research"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2008-02-05","prism:volume":"86","prism:number":"8","prism:startingPage":"1758","prism:endingPage":"1767"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjnr.21625"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jnr.21625"}],"createdAt":"2008-02-05","modifiedAt":"2023-10-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium-Binding%20Proteins","dc:title":"Calcium-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Microfilament%20Proteins","dc:title":"Microfilament Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Bone%20Marrow%20Cells","dc:title":"Bone Marrow Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Cochlea","dc:title":"Cochlea"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Evoked%20Potentials,%20Auditory,%20Brain%20Stem","dc:title":"Evoked Potentials, Auditory, Brain Stem"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050004953545213568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Early Development of Resident Macrophages in the Mouse Cochlea Depends on Yolk Sac Hematopoiesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1050289321231941248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Csf1 Signaling Regulates Maintenance of Resident Macrophages and Bone Formation in the Mouse Cochlea"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285728713088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium."}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230205696768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Adipose tissue‐derived stromal cells protect hair cells from aminoglycoside"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757453256960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Multiplex immunohistochemistry reveals cochlear macrophage heterogeneity and local auditory nerve inflammation in cisplatin-induced hearing loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187495468544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pharmacological Inhibition of Cochlear Mitochondrial Respiratory Chain Induces Secondary Inflammation in the Lateral Wall: A Potential Therapeutic Target for Sensorineural Hearing Loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645589371520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immune system of the inner ear as a novel therapeutic target for sensorineural hearing loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645589391488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593750616832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tissue-Resident Macrophages in the Stria Vascularis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861289652315392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of Inner Ear Macrophages and Autoimmune/Autoinflammatory Mechanisms in the Pathophysiology of Inner Ear Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865814752477056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Contribution of circulating monocytes in maintaining homeostasis of resident macrophages in postnatal and young adult mouse cochlea"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815691574144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Signaling pathways regulating the immune function of cochlear supporting cells and their involvement in cochlear pathophysiology"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975843216520192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204950634752","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"内耳再生医療"},{"@language":"en","@value":"Inner ear regeneration therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288073583360","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"内耳の免疫と組織マクロファージ"},{"@language":"en","@value":"Immune system and resident macrophages in the inner ear"}]},{"@id":"https://cir.nii.ac.jp/crid/1390580472188474240","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pathology and Pharmacotherapeutics of Immune-mediated Sensorineural Hearing Loss"},{"@language":"ja","@value":"免疫機構の関与する感音難聴の病態と治療"},{"@language":"ja-Kana","@value":"メンエキ キコウ ノ カンヨ スル カンオン ナンチョウ ノ ビョウタイ ト チリョウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/jnr.21625"},{"@type":"OPENAIRE","@value":"doi_dedup___::554e6d655e8f14137275b72993204383"},{"@type":"CROSSREF","@value":"10.1002/lary.21551_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3389/fneur.2022.1015014_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0090089_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.1016/j.micinf.2013.04.008_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.5648/jjiao.36.233_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.5631/jibirin.117.99_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3389/fphar.2014.00205_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3389/fphar.2014.00287_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3389/fneur.2019.01244_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3757/jser.73.538_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3389/fneur.2022.818395_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3389/fneur.2022.861992_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.1038/s41598-023-50634-y_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.1002/glia.24476_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.1038/s41598-020-63654-9_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"},{"@type":"CROSSREF","@value":"10.3389/fneur.2019.01115_references_DOI_4YXOO396e8u222kUQzjJZdTVd6e"}]}