{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044550412928.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0092-8674(95)90147-7"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0092867495901477?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0092867495901477?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"8548808"}},{"identifier":{"@type":"NAID","@value":"30010683831"}}],"dc:title":[{"@value":"Impaired synapse elimination during cerebellar development in PKCγ mutant mice"}],"description":[{"notation":[{"@value":"PKC gamma is highly expressed in Purkinje cells (PCs) but not in other types of neurons in the cerebellum. The expression of PKC gamma changes markedly during cerebellar development, being very low at birth and reaching a peak around the third postnatal week. This temporal pattern of PKC gamma expression coincides with the developmental transition from multiple to single climbing fiber innervation onto each PC. In adult mutant mice deficient in PKC gamma, we found that 41% of PCs are still innervated by multiple climbing fibers, while other aspects of the cerebellum including the morphology and excitatory synaptic transmission of PCs appear normal. Thus, elimination of multiple climbing fiber innervation appears to be specifically impaired in the mutant cerebellum. We suggest that the developmental role of PKC gamma may be to act as a downstream element in the signal cascade necessary for the elimination of surplus climbing fiber synapses."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044550412930","@type":"Researcher","foaf:name":[{"@value":"Masanobu Kano"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550412928","@type":"Researcher","foaf:name":[{"@value":"Kouichi Hashimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550412929","@type":"Researcher","foaf:name":[{"@value":"Chong Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550413056","@type":"Researcher","foaf:name":[{"@value":"Asa Abeliovich"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550413058","@type":"Researcher","foaf:name":[{"@value":"Atsu Aiba"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550413059","@type":"Researcher","foaf:name":[{"@value":"Hideo Kurihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550413057","@type":"Researcher","foaf:name":[{"@value":"Masahiko Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550413060","@type":"Researcher","foaf:name":[{"@value":"Yoshiro Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044550412931","@type":"Researcher","foaf:name":[{"@value":"Susumu Tonegawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00928674"}],"prism:publicationName":[{"@value":"Cell"}],"dc:publisher":[{"@value":"Elsevier 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Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20N-Methyl-D-Aspartate","dc:title":"Receptors, N-Methyl-D-Aspartate"},{"@id":"https://cir.nii.ac.jp/all?q=Electrophysiology","dc:title":"Electrophysiology"},{"@id":"https://cir.nii.ac.jp/all?q=Isoenzymes","dc:title":"Isoenzymes"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Kinetics","dc:title":"Kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Neurologic%20Mutants","dc:title":"Mice, Neurologic Mutants"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Electron","dc:title":"Microscopy, Electron"},{"@id":"https://cir.nii.ac.jp/all?q=Purkinje%20Cells","dc:title":"Purkinje Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Cerebellum","dc:title":"Cerebellum"},{"@id":"https://cir.nii.ac.jp/all?q=Synapses","dc:title":"Synapses"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Kinase%20C","dc:title":"Protein Kinase C"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050018218948124928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dgkγ knock-out mice show impairments in cerebellar motor coordination, Ltd, and the dendritic development of purkinje cells through the activation of pkcγ"}]},{"@id":"https://cir.nii.ac.jp/crid/1050022457824736128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje 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