{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044642015744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2019/5080843"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/omcl/2019/5080843.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/omcl/2019/5080843.xml"}}],"dc:title":[{"@value":"Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates lipid peroxidation chain reactions, and subsequently induces different types of cell death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how ROS propagate lipid peroxidation chain reactions and how the products of lipid peroxidation initiate apoptosis and autophagy in current models. We also discussed the mechanism of lipid peroxidation during ferroptosis, and we summarized lipid peroxidation in pathological conditions of critical illness. We aim to bring a more global and integrative sight to know how different ROS-induced lipid peroxidation occurs among apoptosis, autophagy, and ferroptosis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044642015749","@type":"Researcher","foaf:name":[{"@value":"Lian-Jiu Su"}],"jpcoar:affiliationName":[{"@value":"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044642015744","@type":"Researcher","foaf:name":[{"@value":"Jia-Hao Zhang"}],"jpcoar:affiliationName":[{"@value":"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044642015747","@type":"Researcher","foaf:name":[{"@value":"Hernando Gomez"}],"jpcoar:affiliationName":[{"@value":"Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, 15223 PA, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044642015745","@type":"Researcher","foaf:name":[{"@value":"Raghavan Murugan"}],"jpcoar:affiliationName":[{"@value":"Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, 15223 PA, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044642015750","@type":"Researcher","foaf:name":[{"@value":"Xing Hong"}],"jpcoar:affiliationName":[{"@value":"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044642015616","@type":"Researcher","foaf:name":[{"@value":"Dongxue Xu"}],"jpcoar:affiliationName":[{"@value":"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044642015746","@type":"Researcher","foaf:name":[{"@value":"Fan Jiang"}],"jpcoar:affiliationName":[{"@value":"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044642015748","@type":"Researcher","foaf:name":[{"@value":"Zhi-Yong Peng"}],"jpcoar:affiliationName":[{"@value":"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China"},{"@value":"Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, 15223 PA, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19420900"},{"@type":"EISSN","@value":"19420994"}],"prism:publicationName":[{"@value":"Oxidative Medicine and Cellular 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