{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044820175360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/eurheartj/ehu210"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/eurheartj/article-pdf/35/30/2021/17354542/ehu210.pdf"}},{"identifier":{"@type":"PMID","@value":"24908391"}},{"identifier":{"@type":"HANDLE","@value":"11588/591959"}},{"identifier":{"@type":"HANDLE","@value":"11573/1660451"}}],"dc:title":[{"@value":"A randomized, prospective, intercontinental evaluation of a bioresorbable polymer sirolimus-eluting coronary stent system: the CENTURY II (Clinical Evaluation of New Terumo Drug-Eluting Coronary Stent System in the Treatment of Patients with Coronary Artery Disease) trial"}],"description":[{"notation":[{"@value":"The aim of this study was to establish safety and efficacy of a new sirolimus-eluting stent with bioresorbable polymer, Ultimaster (BP-SES). Sirolimus-eluting stent with bioresorbable polymer was compared with everolimus-eluting, permanent polymer, Xience stent (PP-EES) in the frame of a CENTURY II clinical trial designed to make global clinical data compliant with regulatory requirements in Europe and Japan.The CENTURY II is a prospective, multicentre, randomized (1 : 1), single blind, controlled, non-inferiority clinical trial conducted at 58 study sites in Japan, Europe, and Korea. A total of 1123 patients requiring a percutaneous coronary intervention (PCI) procedure, with implantation of drug-eluting stent (DES), were enrolled [total population (TP)]. Randomization of patients was stratified for the subset of patients matching requirements for DES in Japan (Cohort JR, n = 722). Baseline patient demographic and angiographic characteristics were similar in both study arms, with minimal differences between the TP and Cohort JR. The primary endpoint, freedom from target lesion failure (TLF) at 9 months-TLF [composite of cardiac death, target-vessel-related myocardial infarction (MI) and target lesion revascularization]-was 95.6% with BP-SES and 95.1% with PP-EES (Pnon-inferiority0.0001). Composite of cardiac death and MI rate was 2.9 and 3.8% (P = 0.40) and target vessel revascularization was 4.5% with BP-SES and 4.2% with PP-EES (P = 0.77). The stent thrombosis rate was 0.9% in both arms. In Cohort JR, freedom from TLF was 95.9 and 94.6% (Pnon-inferiority0.0005) with BP-SES and PP-EES, respectively.The new bioresorbable polymer sirolimus-eluting stent showed safety and efficacy profiles similar to durable polymer everolimus-eluting stent at 9-month follow-up.UMIN000006940."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380853567795311370","@type":"Researcher","foaf:name":[{"@value":"S. Saito"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175360","@type":"Researcher","foaf:name":[{"@value":"M. Valdes-Chavarri"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175365","@type":"Researcher","foaf:name":[{"@value":"G. Richardt"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175232","@type":"Researcher","foaf:name":[{"@value":"R. Moreno"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175361","@type":"Researcher","foaf:name":[{"@value":"A. Iniguez Romo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175362","@type":"Researcher","foaf:name":[{"@value":"E. Barbato"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175370","@type":"Researcher","foaf:name":[{"@value":"D. Carrie"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175363","@type":"Researcher","foaf:name":[{"@value":"K. Ando"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175369","@type":"Researcher","foaf:name":[{"@value":"B. Merkely"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175233","@type":"Researcher","foaf:name":[{"@value":"R. Kornowski"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175368","@type":"Researcher","foaf:name":[{"@value":"H. Eltchaninoff"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175366","@type":"Researcher","foaf:name":[{"@value":"S. James"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044820175367","@type":"Researcher","foaf:name":[{"@value":"W. Wijns"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0195668X"},{"@type":"EISSN","@value":"15229645"}],"prism:publicationName":[{"@value":"European Heart Journal"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2014-05-19","prism:volume":"35","prism:number":"30","prism:startingPage":"2021","prism:endingPage":"2031"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://academic.oup.com/eurheartj/article-pdf/35/30/2021/17354542/ehu210.pdf"}],"createdAt":"2014-05-20","modifiedAt":"2017-08-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Sirolimus","dc:title":"Sirolimus"},{"@id":"https://cir.nii.ac.jp/all?q=Coronary%20Stenosis","dc:title":"Coronary Stenosis"},{"@id":"https://cir.nii.ac.jp/all?q=Myocardial%20Ischemia","dc:title":"Myocardial Ischemia"},{"@id":"https://cir.nii.ac.jp/all?q=Drug-Eluting%20Stents","dc:title":"Drug-Eluting Stents"},{"@id":"https://cir.nii.ac.jp/all?q=Coronary%20Angiography","dc:title":"Coronary Angiography"},{"@id":"https://cir.nii.ac.jp/all?q=Percutaneous%20Coronary%20Intervention","dc:title":"Percutaneous Coronary Intervention"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Absorbable%20Implants","dc:title":"Absorbable Implants"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Single-Blind%20Method","dc:title":"Single-Blind Method"},{"@id":"https://cir.nii.ac.jp/all?q=Everolimus","dc:title":"Everolimus"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=FASTTrack%20Clinical%20Research","dc:title":"FASTTrack Clinical Research"},{"@id":"https://cir.nii.ac.jp/all?q=Immunosuppressive%20Agents","dc:title":"Immunosuppressive Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285707229683200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Beneficial Effects of a Novel Bioabsorbable Polymer Coating on Enhanced Coronary Vasoconstricting Responses After Drug-Eluting Stent Implantation in Pigs in Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567795311232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine 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