{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044846747136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1182/blood-2008-01-133355"}},{"identifier":{"@type":"URI","@value":"http://ashpublications.org/blood/article-pdf/111/10/5078/1296503/zh801008005078.pdf"}}],"dc:title":[{"@value":"MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Acute myeloid leukemia (AML) is a highly diverse disease characterized by various cytogenetic and molecular abnormalities. MicroRNAs are small noncoding RNAs that show variable expression during myeloid differentiation. MicroRNA expression in marrow blasts in 215 cases of newly diagnosed and (cyto)genetically defined AML was assessed using quantitative reverse-transcription–polymerase chain reaction (RT-PCR) for 260 human microRNAs. In the same series, mRNA gene expression profiles were established, allowing a direct comparison between microRNA and mRNA expression. We show that microRNA expression profiling following unsupervised analysis reveals distinctive microRNA signatures that correlate with cytogenetic and molecular subtypes of AML (ie, AMLs with t(8;21), t(15;17), inv(16), NPM1, and CEBPA mutations). Significantly differentially expressed microRNAs for genetic subtypes of AML were identified. Specific microRNAs with established oncogenic and tumor suppressor functions, such as microRNA-155, microRNA-21, and let-7, appear to be associated with particular subtypes. Combinations of selected sets of microRNAs could predict cytogenetically normal AML with mutations in the genes of NPM1 and CEBPA and FLT3-ITD with similar accuracy as mRNA probe set combinations defined by gene expression profiling. MicroRNA expression apparently bears specific relationships to the heterogeneous pathobiology of AML. Distinctive microRNA signatures appear of potential value in the clinical diagnosis of AML.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044846747140","@type":"Researcher","foaf:name":[{"@value":"Mojca Jongen-Lavrencic"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044846747139","@type":"Researcher","foaf:name":[{"@value":"Su Ming Sun"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044846747138","@type":"Researcher","foaf:name":[{"@value":"Menno K. Dijkstra"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044846747136","@type":"Researcher","foaf:name":[{"@value":"Peter J. M. Valk"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044846747137","@type":"Researcher","foaf:name":[{"@value":"Bob Löwenberg"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00064971"},{"@type":"EISSN","@value":"15280020"}],"prism:publicationName":[{"@value":"Blood"}],"dc:publisher":[{"@value":"American Society of Hematology"}],"prism:publicationDate":"2008-05-15","prism:volume":"111","prism:number":"10","prism:startingPage":"5078","prism:endingPage":"5085"},"reviewed":"false","url":[{"@id":"http://ashpublications.org/blood/article-pdf/111/10/5078/1296503/zh801008005078.pdf"}],"createdAt":"2008-03-13","modifiedAt":"2019-11-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218954605696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711736565760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1182/blood-2008-01-133355"},{"@type":"CROSSREF","@value":"10.1182/blood-2010-03-277012_references_DOI_GJDLHV5SDTdA9JYQbIKJWXptyTi"},{"@type":"CROSSREF","@value":"10.1182/blood-2014-02-554543_references_DOI_GJDLHV5SDTdA9JYQbIKJWXptyTi"}]}