{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044895031424.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1096378"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1096378"}},{"identifier":{"@type":"NAID","@value":"80016698334"}}],"dc:title":[{"@value":"CD8\n                    <sup>+</sup>\n                    T Cell Cross-Priming via Transfer of Proteasome Substrates"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    “Cross-priming” describes the activation of naïve CD8\n                    <jats:sup>+</jats:sup>\n                    T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from “donor” cells. Antigen transfer is believed to be mediated by donor cell–derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8\n                    <jats:sup>+</jats:sup>\n                    T cell responses.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044895031428","@type":"Researcher","foaf:name":[{"@value":"Christopher C. Norbury"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031427","@type":"Researcher","foaf:name":[{"@value":"Sameh Basta"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031425","@type":"Researcher","foaf:name":[{"@value":"Keri B. Donohue"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031424","@type":"Researcher","foaf:name":[{"@value":"David C. Tscharke"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031430","@type":"Researcher","foaf:name":[{"@value":"Michael F. Princiotta"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031431","@type":"Researcher","foaf:name":[{"@value":"Peter Berglund"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031426","@type":"Researcher","foaf:name":[{"@value":"James Gibbs"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031432","@type":"Researcher","foaf:name":[{"@value":"Jack R. Bennink"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044895031429","@type":"Researcher","foaf:name":[{"@value":"Jonathan W. Yewdell"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA."},{"@value":"Department of Microbiology and Immunology, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."},{"@value":"Integrative Biosciences Graduate Program, Option in Molecular Medicine, Pennsylvania State University Huck Institute for Life Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2004-05-28","prism:volume":"304","prism:number":"5675","prism:startingPage":"1318","prism:endingPage":"1321"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1096378"}],"createdAt":"2004-05-27","modifiedAt":"2024-01-09","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360283695108079872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Heat-Shock Proteins as Endogenous Ligands Building a Bridge Between Innate and Adaptive Immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706976699648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661269063552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500415391488","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen-presenting cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974884189696","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"IL-4 deficiency does not impair the ability of dendritic cells to initiate CD4^+ and CD8^+ T cell responses in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668926003359360","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The pathogenicity of self-antigen decreases at high levels of autoantigenicity : a computational approach"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875084080768","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Efficiency of peptide presentation by dendritic cells compared with other cell types : implications for cross-priming"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.1096378"},{"@type":"CIA","@value":"80016698334"},{"@type":"CROSSREF","@value":"10.2217/imt.12.75_references_DOI_WaiXm9R5M6wsOCy8Znlcs5xTVEX"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2010.01.019_references_DOI_WaiXm9R5M6wsOCy8Znlcs5xTVEX"},{"@type":"CROSSREF","@value":"10.1155/2010/752381_references_DOI_WaiXm9R5M6wsOCy8Znlcs5xTVEX"}]}