Angiotensinogen Gene Haplotype and Hypertension

DOI Web Site 7 Citations
  • Chia-Ti Tsai
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Daniele Fallin
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Fu-Tien Chiang
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Juey-Jen Hwang
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Ling-Ping Lai
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Kuan-Lih Hsu
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Chuen-Den Tseng
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Chiau-Suong Liau
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.
  • Yung-Zu Tseng
    From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio.

Bibliographic Information

Other Title
  • Interaction With ACE Gene I Allele
Published
2003-01
DOI
  • 10.1161/01.hyp.0000045080.28739.12
Publisher
Ovid Technologies (Wolters Kluwer Health)

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Description

<jats:p>There are many reports demonstrating the association of renin-angiotensin system gene polymorphisms with hypertension in different populations. In the present study, we used haplotype analyses of the angiotensinogen gene with a new permutation-based hypothesis testing method to determine the association between multilocus angiotensinogen gene polymorphisms and hypertension in a relatively homogeneous Taiwanese population. We also genotyped angiotensin-converting enzyme gene insertion/deletion polymorphism and angiotensin II type 1–receptor gene A1166C polymorphism to detect epistatic gene-gene interactions. There were 408 patients with hypertension (hypertensives) and 286 controls. The angiotensinogen gene haplotype frequencies were significantly different between hypertensives and controls, and this finding was only present in subjects with angiotensin-converting enzyme gene II genotypes when the analysis was stratified by genotype of this polymorphism. In addition, the angiotensinogen gene haplotype structure of hypertensives was more heterogeneous than that of controls. Our results showed that angiotensinogen gene haplotypes were associated with hypertension and might act synergistically with I allele of the angiotensin-converting enzyme gene.</jats:p>

Journal

  • Hypertension

    Hypertension 41 (1), 9-15, 2003-01

    Ovid Technologies (Wolters Kluwer Health)

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