{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044956318976.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.hyp.0000045080.28739.12"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000045080.28739.12"}},{"identifier":{"@type":"NAID","@value":"30022677274"}}],"dc:title":[{"@value":"Angiotensinogen Gene Haplotype and Hypertension"}],"dcterms:alternative":[{"@value":"Interaction With ACE Gene I Allele"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>There are many reports demonstrating the association of renin-angiotensin system gene polymorphisms with hypertension in different populations. In the present study, we used haplotype analyses of the angiotensinogen gene with a new permutation-based hypothesis testing method to determine the association between multilocus angiotensinogen gene polymorphisms and hypertension in a relatively homogeneous Taiwanese population. We also genotyped angiotensin-converting enzyme gene insertion/deletion polymorphism and angiotensin II type 1–receptor gene A1166C polymorphism to detect epistatic gene-gene interactions. There were 408 patients with hypertension (hypertensives) and 286 controls. The angiotensinogen gene haplotype frequencies were significantly different between hypertensives and controls, and this finding was only present in subjects with angiotensin-converting enzyme gene II genotypes when the analysis was stratified by genotype of this polymorphism. In addition, the angiotensinogen gene haplotype structure of hypertensives was more heterogeneous than that of controls. Our results showed that angiotensinogen gene haplotypes were associated with hypertension and might act synergistically with I allele of the angiotensin-converting enzyme gene.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044956318851","@type":"Researcher","foaf:name":[{"@value":"Chia-Ti Tsai"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318854","@type":"Researcher","foaf:name":[{"@value":"Daniele Fallin"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318850","@type":"Researcher","foaf:name":[{"@value":"Fu-Tien Chiang"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318976","@type":"Researcher","foaf:name":[{"@value":"Juey-Jen Hwang"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318852","@type":"Researcher","foaf:name":[{"@value":"Ling-Ping Lai"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318849","@type":"Researcher","foaf:name":[{"@value":"Kuan-Lih Hsu"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318977","@type":"Researcher","foaf:name":[{"@value":"Chuen-Den Tseng"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318853","@type":"Researcher","foaf:name":[{"@value":"Chiau-Suong Liau"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044956318848","@type":"Researcher","foaf:name":[{"@value":"Yung-Zu Tseng"}],"jpcoar:affiliationName":[{"@value":"From the Division of Cardiology, Department of Internal Medicine (C.-T.T., F.-T.C., J.-J.H., L.-P.L., K.-L.H., C.-D.T., C.-S.L., Y.-Z.T.) and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei, Taiwan; and Department of Epidemiology and Biostatistics, Case Western Reserve University (D.F.), Cleveland, Ohio."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2003-01","prism:volume":"41","prism:number":"1","prism:startingPage":"9","prism:endingPage":"15"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000045080.28739.12"}],"createdAt":"2003-01-03","modifiedAt":"2024-05-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235757344128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Angiotensinogen gene haplotype is associated with the prevalence of Japanese non‐alcoholic steatohepatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205037951488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association Between Angiotensin I-Converting Enzyme Gene Insertion/Deletion Polymorphism and Risk of Rheumatic Heart Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679888022784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic Markers for Hypertensive Disorders"},{"@value":"高血圧における遺伝子マーカー"}]},{"@id":"https://cir.nii.ac.jp/crid/1520290882320974976","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"情報間参照構造に基づく関係性解析による疾患関連遺伝子の探索"},{"@language":"ja-Kana","@value":"ジョウホウ カン サンショウ コウゾウ ニ モトヅク カンケイセイ カイセキ ニ ヨル シッカン カンレン イデンシ ノ タンサク"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750769692672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of Hypertension-Susceptibility Genes and Pathways by a Systemic Multiple Candidate Gene Approach : The Millennium Genome Project for Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500632184320","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association between the angiotensinogen gene T174M polymorphism and hypertension risk in the Chinese population : a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976079705984","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association of the angiotensin II type I receptor gene +1166 A>C polymorphism with hypertension risk : evidence from a meta-analysis of 16474 subjects"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/01.hyp.0000045080.28739.12"},{"@type":"CIA","@value":"30022677274"},{"@type":"CROSSREF","@value":"10.1111/j.1872-034x.2011.00883.x_references_DOI_YjqA1NDklSP9UCWPYagCH8NR5jv"},{"@type":"CROSSREF","@value":"10.1536/jhj.45.949_references_DOI_YjqA1NDklSP9UCWPYagCH8NR5jv"}]}