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Key steps in the synthesis include diastereoselective ynone reduction with (-)-alpha-pinene and 9-BBN, macrocyclization by E-selective intramolecular Horner-Wadsworth-Emmons (HWE) reaction, as well as carbometalation under Wipf's conditions, followed by HWE reaction at low temperature to selectively construct the (E)-1-methylpropenyl and (1E,2E)-4-carboxy-1,3-butadienyl substituents."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044973134210","@type":"Researcher","foaf:name":[{"@value":"Takahiro Suzuki"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan, and Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044973134336","@type":"Researcher","foaf:name":[{"@value":"Kenji Usui"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, School of 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