{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044976327296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1071/ch9812231"}},{"identifier":{"@type":"URI","@value":"https://connectsci.au/ch/article-pdf/34/10/2231/93164/ch9812231.pdf"}}],"dc:title":[{"@value":"Synthesis of analogues of GABA. VI. Stereoisomers of\n                    <i>cis</i>\n                    -3-Aminocyclohexanecarboxylic acid"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The syntheses are described of (1 R ,3 S )- and (1 S ,3 R )-3-aminocyclohexanecarboxylic acids via unsaturated intermediates suitable for tritium labelling. The absolute stereochemistry was determined by an alternative synthesis of the (1 R ,3 S ) isomer from (R)-3-oxocyclohexanecarboxylic acid. The (1 S ,3 R ) isomer showed a similar potency to GABA as an inhibitor of the uptake of radioactive GABA by rat brain slices whereas the (1 R ,3 S ) isomer was at least 20 times less potent.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044976327296","@type":"Researcher","foaf:name":[{"@value":"RD Allan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044976327168","@type":"Researcher","foaf:name":[{"@value":"GAR Johnston"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044976327169","@type":"Researcher","foaf:name":[{"@value":"B Twitchin"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00049425"},{"@type":"EISSN","@value":"14450038"}],"prism:publicationName":[{"@value":"Australian Journal of Chemistry"}],"dc:publisher":[{"@value":"CSIRO Publishing"}],"prism:publicationDate":"1981-10-01","prism:volume":"34","prism:number":"10","prism:startingPage":"2231","prism:endingPage":"2236"},"reviewed":"false","dc:rights":["https://doi.org/10.1071/journalslicense"],"url":[{"@id":"https://connectsci.au/ch/article-pdf/34/10/2231/93164/ch9812231.pdf"}],"createdAt":"2010-09-02","modifiedAt":"2025-12-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848654874396544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rhodium‐Catalyzed 1,4‐Addition of Lithium 2‐Furyltriolborates to Unsaturated Ketones and Esters for Enantioselective Synthesis of γ‐Oxo‐Carboxylic Acids By Oxidation of the Furyl Ring with Ozone"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1071/ch9812231"},{"@type":"CROSSREF","@value":"10.1002/asia.201000589_references_DOI_XV5d3cxHDeZkbvuzNXqzNRLAb2V"}]}