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We have demonstrated that 8‐nitroguanine is formed dose‐dependently in calf thymus DNA incubated with low concentrations of peroxynitrite in vitro. 8‐Nitroguanine in acid‐hydrolyzed DNA was chemically reduced into 8‐aminoguanine, which was analyzed using high performance liquid chromatography with electrochemical detection. Only peroxynitrite, but not nitrite, tetranitromethane nor NO‐releasing compounds, formed 8‐nitroguanine. Antioxidants and desferrioxamine inhibited the reaction. 8‐Nitroguanine was depurinated from DNA incubated at pH 7.4, 37°C (<jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"graphic/feb20014579395012816-math-si1.gif\" xlink:title=\"urn:x-wiley:00145793:media:feb20014579395012816:feb20014579395012816-math-si1\"/>). Peroxynitrite did not increase 8‐oxoguanine levels in DNA.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044978023681","@type":"Researcher","foaf:name":[{"@value":"Vladimir Yermilov"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044978023680","@type":"Researcher","foaf:name":[{"@value":"Julieta Rubio"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044978023682","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ohshima"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00145793"},{"@type":"EISSN","@value":"18733468"}],"prism:publicationName":[{"@value":"FEBS 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