{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137044991935232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1086507"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1086507"}}],"dc:title":[{"@value":"The Immunological Synapse Balances T Cell Receptor Signaling and Degradation"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137044991935360","@type":"Researcher","foaf:name":[{"@value":"Kyeong-Hee Lee"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935232","@type":"Researcher","foaf:name":[{"@value":"Aaron R. Dinner"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935233","@type":"Researcher","foaf:name":[{"@value":"Chun Tu"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935363","@type":"Researcher","foaf:name":[{"@value":"Gabriele Campi"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935364","@type":"Researcher","foaf:name":[{"@value":"Subhadip Raychaudhuri"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935238","@type":"Researcher","foaf:name":[{"@value":"Rajat Varma"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935235","@type":"Researcher","foaf:name":[{"@value":"Tasha N. Sims"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935362","@type":"Researcher","foaf:name":[{"@value":"W. Richard Burack"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935361","@type":"Researcher","foaf:name":[{"@value":"Hui Wu"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935234","@type":"Researcher","foaf:name":[{"@value":"Julia Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935237","@type":"Researcher","foaf:name":[{"@value":"Osami Kanagawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935241","@type":"Researcher","foaf:name":[{"@value":"Mary Markiewicz"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935236","@type":"Researcher","foaf:name":[{"@value":"Paul M. Allen"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935239","@type":"Researcher","foaf:name":[{"@value":"Michael L. Dustin"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935240","@type":"Researcher","foaf:name":[{"@value":"Arup K. Chakraborty"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137044991935242","@type":"Researcher","foaf:name":[{"@value":"Andrey S. Shaw"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA."},{"@value":"Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA."},{"@value":"Department of Chemistry, University of California, Berkeley, CA 94720, USA."},{"@value":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA."},{"@value":"Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2003-11-14","prism:volume":"302","prism:number":"5648","prism:startingPage":"1218","prism:endingPage":"1222"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1086507"}],"createdAt":"2003-09-30","modifiedAt":"2024-01-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215970662272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002220912390912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cofilin-Mediated F-Actin Severing Is Regulated by the Rap GTPase and Controls the Cytoskeletal Dynamics That Drive Lymphocyte Spreading and BCR Microcluster Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233407327360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The bullseye synapse formed between CD4<sup>+</sup> T‐cell and staphylococcal enterotoxin B‐pulsed dendritic cell is a suppressive synapse in T‐cell response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710935796224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of T cell activation and function by the adaptor protein CIN85"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170602678912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dynamic Regulation of TCR–Microclusters and the Microsynapse for T Cell Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380128965632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846639848577408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Immunological Synapse, TCR Microclusters, and T Cell Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640900782976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131415411061632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular Dynamics of Co-signal Molecules in T-Cell Activation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.1086507"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1102233_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.1038/icb.2014.76_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.1016/j.immuni.2010.09.006_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.1016/j.immuni.2011.05.012_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.1126/scisignal.aav4373_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2016.00255_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2024.114655_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.1007/978-3-642-03858-7_5_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"},{"@type":"CROSSREF","@value":"10.1007/978-981-32-9717-3_5_references_DOI_C1NztAFlfJhqLpcQ6NaWOBAOAZr"}]}