{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045102499200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.169.3.1151"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/169/3/1151/62555820/1151.pdf"}},{"identifier":{"@type":"PMID","@value":"12133934"}}],"dc:title":[{"@value":"Essential Role of NF-κB-Inducing Kinase in T Cell Activation Through the TCR/CD3 Pathway"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>NF-κB-inducing kinase (NIK) is involved in lymphoid organogenesis in mice through lymphotoxin-β receptor signaling. To clarify the roles of NIK in T cell activation through TCR/CD3 and costimulation pathways, we have studied the function of T cells from aly mice, a strain with mutant NIK. NIK mutant T cells showed impaired proliferation and IL-2 production in response to anti-CD3 stimulation, and these effects were caused by impaired NF-κB activity in both mature and immature T cells; the impaired NF-κB activity in mature T cells was also associated with the failure of maintenance of activated NF-κB. In contrast, responses to costimulatory signals were largely retained in aly mice, suggesting that NIK is not uniquely coupled to the costimulatory pathways. When NIK mutant T cells were stimulated in the presence of a protein kinase C (PKC) inhibitor, proliferative responses were abrogated more severely than in control mice, suggesting that both NIK and PKC control T cell activation in a cooperative manner. We also demonstrated that NIK and PKC are involved in distinct NF-κB activation pathways downstream of TCR/CD3. These results suggest critical roles for NIK in setting the threshold for T cell activation, and partly account for the immunodeficiency in aly mice.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045102499204","@type":"Researcher","foaf:name":[{"@value":"Mitsuru Matsumoto"}],"jpcoar:affiliationName":[{"@value":"Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima , Tokushima ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045102499202","@type":"Researcher","foaf:name":[{"@value":"Takuji Yamada"}],"jpcoar:affiliationName":[{"@value":"First Department of Internal Medicine, School of Medicine, Ehime University , Ehime ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380866922984021120","@type":"Researcher","foaf:name":[{"@value":"Steven K Yoshinaga"}],"jpcoar:affiliationName":[{"@value":"Amgen , Thousand Oaks, CA 91320"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045102499072","@type":"Researcher","foaf:name":[{"@value":"Tom Boone"}],"jpcoar:affiliationName":[{"@value":"Amgen , Thousand Oaks, CA 91320"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045102499203","@type":"Researcher","foaf:name":[{"@value":"Tom Horan"}],"jpcoar:affiliationName":[{"@value":"Amgen , Thousand Oaks, CA 91320"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045102499206","@type":"Researcher","foaf:name":[{"@value":"Shigeru Fujita"}],"jpcoar:affiliationName":[{"@value":"First Department of Internal Medicine, School of Medicine, Ehime University , Ehime ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045102499205","@type":"Researcher","foaf:name":[{"@value":"Yi Li"}],"jpcoar:affiliationName":[{"@value":"Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima , Tokushima ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045102499200","@type":"Researcher","foaf:name":[{"@value":"Tasuku Mitani"}],"jpcoar:affiliationName":[{"@value":"Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima , Tokushima ,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221767"},{"@type":"EISSN","@value":"15506606"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00221767"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2002-08-01","prism:volume":"169","prism:number":"3","prism:startingPage":"1151","prism:endingPage":"1158"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/169/3/1151/62555820/1151.pdf"}],"createdAt":"2014-04-22","modifiedAt":"2025-03-31","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes","dc:title":"T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Serine-Threonine%20Kinases","dc:title":"Protein Serine-Threonine Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=I-kappa%20B%20Kinase","dc:title":"I-kappa B Kinase"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=B-Cell%20Lymphoma%203%20Protein","dc:title":"B-Cell Lymphoma 3 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Receptor-CD3%20Complex,%20Antigen,%20T-Cell","dc:title":"Receptor-CD3 Complex, Antigen, T-Cell"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins","dc:title":"Proto-Oncogene Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappaB-Inducing%20Kinase","dc:title":"NF-kappaB-Inducing Kinase"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-2","dc:title":"Interleukin-2"},{"@id":"https://cir.nii.ac.jp/all?q=Tetradecanoylphorbol%20Acetate","dc:title":"Tetradecanoylphorbol Acetate"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Kinase%20C","dc:title":"Protein Kinase C"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360565170866386816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NF-κB–Inducing Kinase in Thymic Stroma Establishes Central Tolerance by Orchestrating Cross-Talk with Not Only Thymocytes but Also Dendritic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567179896351360","@type":"Article","resourceType":"学術雑誌論文(journal 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development"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680189358336","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Crucial Roles of NF-.KAPPA.B for T Cell Activation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.4049/jimmunol.169.3.1151"},{"@type":"OPENAIRE","@value":"doi_dedup___::9a44d7fec3408d8e6d26b7881cdaed88"},{"@type":"CROSSREF","@value":"10.2330/joralbiosci.48.12_references_DOI_CBFki9V0NBXNHlWegpAnvfhOH9d"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1400389_references_DOI_CBFki9V0NBXNHlWegpAnvfhOH9d"},{"@type":"CROSSREF","@value":"10.1002/art.40230_references_DOI_CBFki9V0NBXNHlWegpAnvfhOH9d"},{"@type":"CROSSREF","@value":"10.1111/imm.12186_references_DOI_CBFki9V0NBXNHlWegpAnvfhOH9d"},{"@type":"CROSSREF","@value":"10.1111/imm.12484_references_DOI_CBFki9V0NBXNHlWegpAnvfhOH9d"}]}