{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045211891840.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.181.2.1454"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/181/2/1454/62582947/7403.pdf"}}],"dc:title":[{"@value":"Systemic Release of High Mobility Group Box 1 Protein during Severe Murine Influenza"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Hypercytokinemia is gaining recognition as the mechanism of fatality from influenza. No work to date has addressed the role of high mobility group box 1 protein (HMGB1) in influenza, the parallel being that in other severe proinflammatory cytokine syndromes (e.g., sepsis and malaria) levels of circulating HMGB1 are elevated and may correlate with death. Using a commercially available ELISA for HMGB1, we found that HMGB1 was not increased in the plasma of influenza virus-infected mice (A/Japan/305/57) on day 7 post infection, about the time of peak mortality, and peak levels of HMGB1 in the plasma did not occur until relatively late in infection, on day 9 post infection. In keeping with the late peak of HMGB1 being unassociated with mortality, administration of ethyl pyruvate, which inhibits active secretion but not passive release of HMGB1, to influenza virus-infected mice, did not affect their survival. Further work is required to determine whether influenza virus infection induces passive release of HMGB1, and whether HMGB1 neutralization with a specific Ab would improve survival.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380307276414062081","@type":"Researcher","foaf:name":[{"@value":"Lisa M Alleva"}],"jpcoar:affiliationName":[{"@value":"School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australian Capital Territory ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380307276414062082","@type":"Researcher","foaf:name":[{"@value":"Alison C Budd"}],"jpcoar:affiliationName":[{"@value":"School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australian Capital Territory ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380307276414062080","@type":"Researcher","foaf:name":[{"@value":"Ian A Clark"}],"jpcoar:affiliationName":[{"@value":"School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australian Capital Territory ,"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"15506606"},{"@type":"PISSN","@value":"00221767"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2008-07","prism:volume":"181","prism:number":"2","prism:startingPage":"1454","prism:endingPage":"1459"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/181/2/1454/62582947/7403.pdf"}],"createdAt":"2014-04-18","modifiedAt":"2026-01-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285707068636544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707243085952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643761543040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Leukocyte‐Derived High‐Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168956999168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182174761600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High-mobility group box family of proteins: ligand and sensor for innate immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679220748544","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Delayed Administration of D-Ala2-D-Leu5-Enkephalin, a Delta-Opioid Receptor Agonist, Improves Survival in a Rat Model of Sepsis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.4049/jimmunol.181.2.1454"},{"@type":"CROSSREF","@value":"10.1620/tjem.224.69_references_DOI_LTRgFapQWfIWGsBiXScqJ4vXBFE"},{"@type":"CROSSREF","@value":"10.1002/hep4.1777_references_DOI_LTRgFapQWfIWGsBiXScqJ4vXBFE"},{"@type":"CROSSREF","@value":"10.1186/s13054-015-0983-9_references_DOI_LTRgFapQWfIWGsBiXScqJ4vXBFE"},{"@type":"CROSSREF","@value":"10.1016/j.jdermsci.2018.01.007_references_DOI_LTRgFapQWfIWGsBiXScqJ4vXBFE"},{"@type":"CROSSREF","@value":"10.1016/j.cyto.2011.07.016_references_DOI_LTRgFapQWfIWGsBiXScqJ4vXBFE"},{"@type":"CROSSREF","@value":"10.1016/j.it.2012.10.005_references_DOI_LTRgFapQWfIWGsBiXScqJ4vXBFE"}]}