{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045246291328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2005.09.107"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X05021315?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X05021315?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"16202978"}},{"identifier":{"@type":"NAID","@value":"30017846849"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Interleukin-1β targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis"}],"description":[{"notation":[{"@value":"Inflammatory bowel disease (IBD) is an immunologically mediated disorder that is characterized by chronic, relapsing, and inflammatory responses. Dextran sulfate sodium (DSS)-induced experimental colitis in mice has been recognized as a useful model for human IBD and interleukin (IL)-1beta is a key cytokine in the onset of IBD. The purpose of the present study was to clarify which pro-inflammatory mediators are targeted by IL-1beta in mice with DSS-induced colitis. First, we found that DSS markedly induced IL-1beta production in both dose- and time-dependent manners (P0.05 and P0.01, respectively) in murine peritoneal macrophages (pMphi), while that of tumor necrosis factor-alpha was insignificant. Further, the expressions of mRNA and protein for IL-1beta were increased in colonic mucosa and pMphi from mice that received drinking water containing 5% DSS for 7 days (P0.01, each). In addition, the expressions of IL-6, granulocyte macrophage-colony stimulating factor, inducible nitric oxide synthase, and cyclooxygenase-2 mRNA were also time dependently increased (P0.01, each). Furthermore, administration of rIL-1beta (10 microg/kg, i.p.) significantly induced the expressions of IL-1beta and IL-6 mRNA in colonic mucosa from non-treated mice (P0.01). Anti-mIL-1beta antibody treatments (50 microg/kg, i.p.) attenuated DSS-induced body weight reduction and shortening of the colorectum (P0.05, each), and abrogated the expressions of IL-1beta and IL-6 mRNA in colonic mucosa (P0.01, each). Our results evidently support the previous findings that IL-1beta is involved in the development of DSS-induced experimental colitis in mice, and strongly suggest that IL-1beta targets itself and IL-6 for progressing colonic inflammation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045246291328","@type":"Researcher","foaf:name":[{"@value":"Ki Han Kwon"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326205883904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10271412"},{"@type":"NRID","@value":"1000010271412"},{"@type":"NRID","@value":"9000238323642"},{"@type":"NRID","@value":"9000237871336"},{"@type":"NRID","@value":"9000020710087"},{"@type":"NRID","@value":"9000021872602"},{"@type":"NRID","@value":"9000261671151"},{"@type":"NRID","@value":"9000018473130"},{"@type":"NRID","@value":"9000024205684"},{"@type":"NRID","@value":"9000415423255"},{"@type":"NRID","@value":"9000021896538"},{"@type":"NRID","@value":"9000022032802"},{"@type":"NRID","@value":"9000404101358"},{"@type":"NRID","@value":"9000018469807"},{"@type":"NRID","@value":"9000018470336"},{"@type":"NRID","@value":"9000259862175"},{"@type":"NRID","@value":"9000001863950"},{"@type":"NRID","@value":"9000016525642"},{"@type":"NRID","@value":"9000283587822"},{"@type":"NRID","@value":"9000283423074"},{"@type":"NRID","@value":"9000018474241"},{"@type":"NRID","@value":"9000336385872"},{"@type":"NRID","@value":"9000007040945"},{"@type":"NRID","@value":"9000283154495"},{"@type":"NRID","@value":"9000021814811"},{"@type":"NRID","@value":"9000018474184"},{"@type":"NRID","@value":"9000412546953"},{"@type":"NRID","@value":"9000024152628"},{"@type":"NRID","@value":"9000347361573"},{"@type":"NRID","@value":"9000415311390"},{"@type":"NRID","@value":"9000409781433"},{"@type":"NRID","@value":"9000383075256"},{"@type":"NRID","@value":"9000412546911"},{"@type":"NRID","@value":"9000254710910"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sftnetts"}],"foaf:name":[{"@value":"Akira Murakami"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045246291457","@type":"Researcher","foaf:name":[{"@value":"Ryohei Hayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045246291329","@type":"Researcher","foaf:name":[{"@value":"Hajime Ohigashi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2005-11","prism:volume":"337","prism:number":"2","prism:startingPage":"647","prism:endingPage":"654"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X05021315?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X05021315?httpAccept=text/plain"}],"createdAt":"2005-09-27","modifiedAt":"2019-03-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-6","dc:title":"Interleukin-6"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Necrosis%20Factor-alpha","dc:title":"Tumor Necrosis Factor-alpha"},{"@id":"https://cir.nii.ac.jp/all?q=Dextran%20Sulfate","dc:title":"Dextran Sulfate"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression","dc:title":"Gene Expression"},{"@id":"https://cir.nii.ac.jp/all?q=Granulocyte-Macrophage%20Colony-Stimulating%20Factor","dc:title":"Granulocyte-Macrophage Colony-Stimulating Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Colitis","dc:title":"Colitis"},{"@id":"https://cir.nii.ac.jp/all?q=Inflammatory%20Bowel%20Diseases","dc:title":"Inflammatory Bowel Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages,%20Peritoneal","dc:title":"Macrophages, Peritoneal"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-1","dc:title":"Interleukin-1"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256864170368","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16613004"},{"@type":"JGN","@value":"JP16613004"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16613004/"}],"notation":[{"@language":"ja","@value":"ラウリル酸の炎症メディエーター産生増強作用とリスクアセスメント"},{"@language":"en","@value":"Effects of lauric acid on the production of pro-inflammatory mediators and its risk assessment"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216662834688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oral Administration of Hen Egg White Ovotransferrin Attenuates the Development of Colitis Induced by Dextran Sodium Sulfate in 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