Msx1 Cooperates with Histone H1b for Inhibition of Transcription and Myogenesis

DOI Web Site 被引用文献9件
  • Hansol Lee
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey (UMDNJ)–Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
  • Raymond Habas
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey (UMDNJ)–Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
  • Cory Abate-Shen
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey (UMDNJ)–Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

書誌事項

公開日
2004-06-11
DOI
  • 10.1126/science.1098096
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> During embryogenesis, differentiation of skeletal muscle is regulated by transcription factors that include members of the Msx homeoprotein family. By investigating Msx1 function in repression of myogenic gene expression, we identified a physical interaction between Msx1 and H1b, a specific isoform of mouse histone H1. We found that Msx1 and H1b bind to a key regulatory element of <jats:italic>MyoD</jats:italic> , a central regulator of skeletal muscle differentiation, where they induce repressed chromatin. Moreover, Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture and in <jats:italic>Xenopus</jats:italic> animal caps. Our findings define a previously unknown function for “linker” histones in gene-specific transcriptional regulation. </jats:p>

収録刊行物

  • Science

    Science 304 (5677), 1675-1678, 2004-06-11

    American Association for the Advancement of Science (AAAS)

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