{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045477684352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/jcs.038232"}},{"identifier":{"@type":"URI","@value":"https://journals.biologists.com/jcs/article-pdf/122/12/2034/2126254/2034.pdf"}}],"dc:title":[{"@value":"The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The rate and direction of axon and dendrite growth depend on multiple guidance signals and growth factors. Semaphorin 3A (Sema3A) acts as a repellent for axons and attractant for dendrites. Here, we show that the requirement for integrin engagement distinguishes the response of axons and dendrites to Sema3A in hippocampal neurons. Sema3A promotes the extension of hippocampal dendrites by a pathway that requires focal adhesion kinase (FAK). The stimulation of dendrite growth and FAK phosphorylation by Sema3A depend on integrin engagement. Unlike their function as a target of Sema3A during the collapse of axonal growth cones, integrins facilitate the stimulation of dendrite extension. Conditional inactivation of the genes encoding β1 integrin or FAK blocks the growth-promoting effect of Sema3A but not the collapse of axonal growth cones. Our results demonstrate that different pathways mediate the stimulation of dendrite growth and the collapse of axonal growth cones by Sema3A.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045477684354","@type":"Researcher","foaf:name":[{"@value":"Uwe Schlomann"}],"jpcoar:affiliationName":[{"@value":"Institut für Allgemeine Zoologie und Genetik, Westfalische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045477684480","@type":"Researcher","foaf:name":[{"@value":"Jens C. Schwamborn"}],"jpcoar:affiliationName":[{"@value":"Institut für Allgemeine Zoologie und Genetik, Westfalische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045477684352","@type":"Researcher","foaf:name":[{"@value":"Myriam Müller"}],"jpcoar:affiliationName":[{"@value":"Institut für Allgemeine Zoologie und Genetik, Westfalische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045477684353","@type":"Researcher","foaf:name":[{"@value":"Reinhard Fässler"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Medicine, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045477684481","@type":"Researcher","foaf:name":[{"@value":"Andreas W. Püschel"}],"jpcoar:affiliationName":[{"@value":"Institut für Allgemeine Zoologie und Genetik, Westfalische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779137"},{"@type":"PISSN","@value":"00219533"}],"prism:publicationName":[{"@value":"Journal of Cell Science"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2009-06-15","prism:volume":"122","prism:number":"12","prism:startingPage":"2034","prism:endingPage":"2042"},"reviewed":"false","url":[{"@id":"https://journals.biologists.com/jcs/article-pdf/122/12/2034/2126254/2034.pdf"}],"createdAt":"2009-05-20","modifiedAt":"2022-01-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232024317824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233430038528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plexin-A4-dependent retrograde semaphorin 3A signalling regulates the dendritic localization of GluA2-containing AMPA receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705285047296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180041714048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184565754624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656954398592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Voltage-gated calcium and sodium channels mediate Sema3A retrograde signaling that regulates dendritic development"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1242/jcs.038232"},{"@type":"CROSSREF","@value":"10.1038/ncomms4424_references_DOI_839zOiziEzfUfpHbnTXfHT1KUag"},{"@type":"CROSSREF","@value":"10.1002/stem.2639_references_DOI_839zOiziEzfUfpHbnTXfHT1KUag"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2016.11.003_references_DOI_839zOiziEzfUfpHbnTXfHT1KUag"},{"@type":"CROSSREF","@value":"10.1002/dneu.22048_references_DOI_839zOiziEzfUfpHbnTXfHT1KUag"},{"@type":"CROSSREF","@value":"10.1093/intimm/dxv014_references_DOI_839zOiziEzfUfpHbnTXfHT1KUag"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2015.11.034_references_DOI_839zOiziEzfUfpHbnTXfHT1KUag"}]}