{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045654290816.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0014-5793(00)01710-5"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2800%2901710-5"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(00)01710-5"}},{"identifier":{"@type":"URI","@value":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2800%2901710-5"}},{"identifier":{"@type":"PMID","@value":"10913633"}}],"dc:title":[{"@value":"Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and <i>Aldh2</i> gene targeting mouse"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>A principal pathway of 2‐methoxyethanol (ME) metabolism is to the toxic oxidative product, methoxyacetaldehyde (MALD). To assess the role of aldehyde dehydrogenase (ALDH) in MALD metabolism, in vitro MALD oxidation was examined with liver subcellular fractions from Japanese subjects who carried three different <jats:italic>ALDH2</jats:italic> genotypes and <jats:italic>Aldh2</jats:italic> knockout mice, which were generated in this study. The activity was distributed in mitochondrial fractions of <jats:italic>ALDH2*1/*1</jats:italic> and wild type (<jats:italic>Aldh2</jats:italic>+/+) mice but not <jats:italic>ALDH2*1/*2</jats:italic>, <jats:italic>*2/*2</jats:italic> subjects or <jats:italic>Aldh2</jats:italic> homozygous mutant (<jats:italic>Aldh2</jats:italic>−/−) mice. These data suggest that ALDH2 is a key enzyme for MALD oxidation and ME susceptibility may be influenced by the <jats:italic>ALDH2</jats:italic> genotype.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045654290820","@type":"Researcher","foaf:name":[{"@value":"Kyoko Kitagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045654290821","@type":"Researcher","foaf:name":[{"@value":"Toshihiro Kawamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045654290822","@type":"Researcher","foaf:name":[{"@value":"Naoki Kunugita"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045654290817","@type":"Researcher","foaf:name":[{"@value":"Tadasuke Tsukiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045654290823","@type":"Researcher","foaf:name":[{"@value":"Kohji Okamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045654290816","@type":"Researcher","foaf:name":[{"@value":"Akira Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045654290819","@type":"Researcher","foaf:name":[{"@value":"Keiko Nakayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045654290818","@type":"Researcher","foaf:name":[{"@value":"Kei-ichi Nakayama"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00145793"},{"@type":"EISSN","@value":"18733468"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00145793"}],"prism:publicationName":[{"@value":"FEBS Letters"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2000-07-03","prism:volume":"476","prism:number":"3","prism:startingPage":"306","prism:endingPage":"311"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2800%2901710-5"},{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(00)01710-5"},{"@id":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2800%2901710-5"}],"createdAt":"2002-07-25","modifiedAt":"2023-09-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Genotype","dc:title":"Genotype"},{"@id":"https://cir.nii.ac.jp/all?q=Acetaldehyde","dc:title":"Acetaldehyde"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Vitro%20Techniques","dc:title":"In Vitro Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=2-Methoxyethanol","dc:title":"2-Methoxyethanol"},{"@id":"https://cir.nii.ac.jp/all?q=Alleles","dc:title":"Alleles"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Primers","dc:title":"DNA Primers"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20targeting%20mouse","dc:title":"Gene targeting mouse"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Polymorphism,%20Genetic","dc:title":"Polymorphism, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Aldehyde%20Dehydrogenase,%20Mitochondrial","dc:title":"Aldehyde Dehydrogenase, Mitochondrial"},{"@id":"https://cir.nii.ac.jp/all?q=Aldehyde%20Dehydrogenase","dc:title":"Aldehyde Dehydrogenase"},{"@id":"https://cir.nii.ac.jp/all?q=Methoxyacetaldehyde","dc:title":"Methoxyacetaldehyde"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Aldehyde%20dehydrogenase%202","dc:title":"Aldehyde dehydrogenase 2"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidation-Reduction","dc:title":"Oxidation-Reduction"},{"@id":"https://cir.nii.ac.jp/all?q=Subcellular%20Fractions","dc:title":"Subcellular Fractions"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282677603042176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of the common polymorphism in the human aldehyde 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gene polymorphisms—The Yamanashi Adjunct Study of the Japan Environment and Children's Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131416072553856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High Ethanol and Acetaldehyde Inhibit Glutamatergic Transmission in the Hippocampus of Aldh2-Knockout and C57BL/6N Mice: an In Vivo and Ex Vivo Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204279717504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Aldh2 Knockout Mice Were More Sensitive to DNA Damage in Leukocytes due to Ethyl Tertiary Butyl Ether Exposure"},{"@value":"Aldh2 Knockout Mice Were More Sensitive to DNA Damage in Leukocyte due to Ethyl Tertiary Butyl Ether 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