{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045678795648.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0091-3057(94)90151-1"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0091305794901511?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0091305794901511?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"7911577"}}],"dc:title":[{"@value":"2-Thiazolylethylamine, a selective histamine H1 agonist, decreases seizure susceptibility in mice"}],"description":[{"notation":[{"@value":"The effects of intracerebroventricular (ICV) administration of histamine and its selective agonists on electrically and pentylenetetrazole-induced convulsions in mice were studied. The ICV administration of histamine decreased seizure susceptibility on electrically and pentylenetetrazole-induced convulsions significantly and dose-dependently. The inhibitory effects of histamine were well antagonized by centrally acting histamine H1 antagonists such as pyrilamine (or mepyramine) and ketotifen, but not by a peripherally acting histamine H1 antagonist, astemizole, or a centrally acting H2 antagonist, zolantidine. The ICV administration of 2-thiazolylethylamine, a selective histamine H1 agonist, also decreased seizure susceptibility, which could be antagonized by centrally acting histamine H1 antagonists, whereas dimaprit, a selective histamine H2 agonist, did not affect seizure susceptibility. These findings strengthened the idea that the central histaminergic neuron system plays an inhibitory role in convulsions."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045678795650","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Yokoyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045678795649","@type":"Researcher","foaf:name":[{"@value":"Kenji Onodera"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045678795651","@type":"Researcher","foaf:name":[{"@value":"Kazuie Iinuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045678795648","@type":"Researcher","foaf:name":[{"@value":"Takehiko Watanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00913057"}],"prism:publicationName":[{"@value":"Pharmacology Biochemistry and Behavior"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1994-03","prism:volume":"47","prism:number":"3","prism:startingPage":"503","prism:endingPage":"507"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:0091305794901511?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:0091305794901511?httpAccept=text/plain"}],"createdAt":"2002-12-14","modifiedAt":"2019-04-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Electroshock","dc:title":"Electroshock"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20Strains","dc:title":"Mice, Inbred Strains"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine%20Agonists","dc:title":"Histamine Agonists"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Thiazoles","dc:title":"Thiazoles"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine%20H2%20Antagonists","dc:title":"Histamine H2 Antagonists"},{"@id":"https://cir.nii.ac.jp/all?q=Dimaprit","dc:title":"Dimaprit"},{"@id":"https://cir.nii.ac.jp/all?q=Seizures","dc:title":"Seizures"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine%20H1%20Antagonists","dc:title":"Histamine H1 Antagonists"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Pentylenetetrazole","dc:title":"Pentylenetetrazole"},{"@id":"https://cir.nii.ac.jp/all?q=Anticonvulsants","dc:title":"Anticonvulsants"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Histamine%20H1","dc:title":"Receptors, Histamine H1"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine","dc:title":"Histamine"},{"@id":"https://cir.nii.ac.jp/all?q=Injections,%20Intraventricular","dc:title":"Injections, Intraventricular"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204272611200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Towards Understanding Mechanisms of Drug Action and Functions of the Body on the Molecular Level. Studies on histamine with L-histidine decarboxylase, a histamine-forming enzyme, as a probe: from purification to gene knockout."},{"@language":"ja","@value":"薬の作用機序と生体機能の分子的理解に向けて　　ヒスタミンに関する研究　　ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@value":"ヒスタミンに関する研究:ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@language":"ja-Kana","@value":"ヒスタミン ニ カンスル ケンキュウ ヒスチジン ダツタンサン コウソ ノ セイセイ カラ ケッソン マウス マデ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679261190912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Histamine H1-Receptors in the Anticonvulsive Effect of Morphine against Maximal Electroconvulsive Shock in Mice."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/0091-3057(94)90151-1"},{"@type":"OPENAIRE","@value":"doi_dedup___::617f3232d4bb4266e721658bc93bb9dd"},{"@type":"CROSSREF","@value":"10.1254/fpj.118.159_references_DOI_P9JyvKlviilozeLsc5zefbYUc9S"},{"@type":"CROSSREF","@value":"10.1254/jjp.71.109_references_DOI_P9JyvKlviilozeLsc5zefbYUc9S"}]}