{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045804485760.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1099/vir.0.038455-0"}},{"identifier":{"@type":"URI","@value":"https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.038455-0?crawler=true"}}],"dc:title":[{"@value":"Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean–Congo hemorrhagic fever virus"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Hazara virus (HAZV) is closely related to the Crimean–Congo hemorrhagic fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose–response effects were seen with higher doses, resulting in a shorter time to death and earlier detection of viral loads in organs. The lowest dose of 10 p.f.u. was still lethal in over 50 % of the mice. Histopathological findings were identified in the liver, spleen and lymph nodes, with changes similar to a recent mouse model of CCHFV infection. The findings demonstrate that inoculation of mice with HAZV may act as a useful surrogate model for the testing of antiviral agents against CCHFV.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045804485888","@type":"Researcher","foaf:name":[{"@value":"Stuart D. Dowall"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485763","@type":"Researcher","foaf:name":[{"@value":"Stephen Findlay-Wilson"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485761","@type":"Researcher","foaf:name":[{"@value":"Emma Rayner"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485762","@type":"Researcher","foaf:name":[{"@value":"Geoff Pearson"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485764","@type":"Researcher","foaf:name":[{"@value":"Janice Pickersgill"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485890","@type":"Researcher","foaf:name":[{"@value":"Antony Rule"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485765","@type":"Researcher","foaf:name":[{"@value":"Natasha Merredew"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485889","@type":"Researcher","foaf:name":[{"@value":"Hazel Smith"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485766","@type":"Researcher","foaf:name":[{"@value":"John Chamberlain"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045804485760","@type":"Researcher","foaf:name":[{"@value":"Roger Hewson"}],"jpcoar:affiliationName":[{"@value":"Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221317"},{"@type":"EISSN","@value":"14652099"}],"prism:publicationName":[{"@value":"Journal of General Virology"}],"dc:publisher":[{"@value":"Microbiology Society"}],"prism:publicationDate":"2012-03-01","prism:volume":"93","prism:number":"3","prism:startingPage":"560","prism:endingPage":"564"},"reviewed":"false","url":[{"@id":"https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.038455-0?crawler=true"}],"createdAt":"2011-11-17","modifiedAt":"2021-12-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050010566081876096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A screen of 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