{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045827680896.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m105383200"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S002192581934815X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S002192581934815X?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M105383200"}},{"identifier":{"@type":"PMID","@value":"11429414"}},{"identifier":{"@type":"NAID","@value":"80012610145"}}],"dc:title":[{"@value":"Induction of Cellular Antioxidative Stress Genes through Heterodimeric Transcription Factor Nrf2/Small Maf by Antirheumatic Gold(I) Compounds"}],"description":[{"notation":[{"@value":"Gold(I)-containing compounds have long been used in the treatment of rheumatoid arthritis (RA), but the molecular mechanism of their action has remained largely unknown. In this paper we have demonstrated that gold(I) drugs selectively activate the DNA binding of a heterodimer consisting of the basic-leucine zipper transcription factors Nrf2 and small Maf. Once bound to its recognition DNA sequence termed antioxidant-responsive element or Maf-recognition element, Nrf2/small Maf induces a set of antioxidative stress genes, including heme oxygenase-1 and gamma-glutamylcysteine synthetase, whose products have been demonstrated to contribute to the scavenging of reactive oxygen species and to exhibit anti-inflammatory effects. Our findings suggest that stimulation of antioxidative stress response through activation of Nrf2/small Maf may be a pharmacologically important part of the actions of gold(I) drugs for the treatment of rheumatoid arthritis. Alternatively, activation of Nrf2/small Maf may be a protective response of cells against toxic effects of the drugs."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045827680898","@type":"Researcher","foaf:name":[{"@value":"Kohsuke Kataoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045827680897","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Handa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045827680896","@type":"Researcher","foaf:name":[{"@value":"Makoto Nishizawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"}],"prism:publicationName":[{"@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2001-09","prism:volume":"276","prism:number":"36","prism:startingPage":"34074","prism:endingPage":"34081"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S002192581934815X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S002192581934815X?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M105383200"}],"createdAt":"2002-07-26","modifiedAt":"2022-01-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Transcriptional%20Activation","dc:title":"Transcriptional Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription,%20Genetic","dc:title":"Transcription, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=NF-E2-Related%20Factor%202","dc:title":"NF-E2-Related Factor 2"},{"@id":"https://cir.nii.ac.jp/all?q=Glutamate-Cysteine%20Ligase","dc:title":"Glutamate-Cysteine Ligase"},{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Fusion%20Proteins","dc:title":"Recombinant Fusion Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Down-Regulation","dc:title":"Down-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Jurkat%20Cells","dc:title":"Jurkat Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Luciferases","dc:title":"Luciferases"},{"@id":"https://cir.nii.ac.jp/all?q=Leucine%20Zippers","dc:title":"Leucine Zippers"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Proteins","dc:title":"Membrane Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=U937%20Cells","dc:title":"U937 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Binding%20Proteins","dc:title":"DNA-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Fluorescence","dc:title":"Microscopy, Fluorescence"},{"@id":"https://cir.nii.ac.jp/all?q=Antirheumatic%20Agents","dc:title":"Antirheumatic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Heme%20Oxygenase%20(Decyclizing)","dc:title":"Heme Oxygenase (Decyclizing)"},{"@id":"https://cir.nii.ac.jp/all?q=Trans-Activators","dc:title":"Trans-Activators"},{"@id":"https://cir.nii.ac.jp/all?q=RNA","dc:title":"RNA"},{"@id":"https://cir.nii.ac.jp/all?q=Gold","dc:title":"Gold"},{"@id":"https://cir.nii.ac.jp/all?q=Dimerization","dc:title":"Dimerization"},{"@id":"https://cir.nii.ac.jp/all?q=Heme%20Oxygenase-1","dc:title":"Heme Oxygenase-1"},{"@id":"https://cir.nii.ac.jp/all?q=HeLa%20Cells","dc:title":"HeLa Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Plasmids","dc:title":"Plasmids"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050566774865104768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690909500672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The possible repositioning of an oral anti-arthritic drug, auranofin, for Nrf2-activating therapy: The demonstration of Nrf2-dependent anti-oxidative action using a zebrafish 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