{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045954620160.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000151772"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/151772"}}],"dc:title":[{"@value":"Reversible Acute Kidney Injury following Contrast Exposure and the Risk of Long-Term Mortality"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><i>Background:</i> Contrast-induced acute kidney injury (AKI) is a significant cause of morbidity and mortality among hospitalized patients. However, data regarding the long-term prognostic implications of reversible AKI following contrast exposure are limited. <i>Methods:</i> We carried out a prospective 5-year follow-up study of 78 patients with chronic kidney disease who underwent coronary angiography, employing a uniform intravenous hydration protocol supplemented by either acetylcysteine (600 mg orally t.i.d.) or placebo. <i>Results:</i> Contrast-induced AKI (defined as ≥0.5 mg/dl increase in serum creatinine, SCr, or >25% increase above baseline 48 h following contrast exposure) developed in 10 of the 78 patients (13%). All SCr changes were reversible, and were no longer evident 7 days following contrast exposure. At 5 years of follow-up, mortality rates were significantly higher among patients who developed reversible AKI (90%) as compared with those who did not (32%; p < 0.001). Accordingly, multivariable analysis demonstrated that reversible AKI was independently associated with a significant 2.7-fold increase (p = 0.001) in the risk of long-term mortality. <i>Conclusions:</i> Our findings indicate that short-term reductions in renal function following contrast exposure have important long-term prognostic implications in patients with chronic kidney disease. Careful follow-up of SCr levels following contrast exposure is warranted for long-term risk assessment in this population.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045954620162","@type":"Researcher","foaf:name":[{"@value":"Ilan Goldenberg"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045954620160","@type":"Researcher","foaf:name":[{"@value":"Michel Chonchol"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045954620161","@type":"Researcher","foaf:name":[{"@value":"Victor Guetta"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02508095"},{"@type":"EISSN","@value":"14219670"}],"prism:publicationName":[{"@value":"American Journal of Nephrology"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2008-08-28","prism:volume":"29","prism:number":"2","prism:startingPage":"136","prism:endingPage":"144"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/151772"}],"createdAt":"2008-09-01","modifiedAt":"2024-05-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235499495808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Does the development of chronic kidney disease and acute kidney injury affect the prognosis after living donor liver transplantation?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206335499904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Contrast-induced Acute Kidney Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680083638912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Proteinuria and Reduced Estimated Glomerular Filtration Rate Are Independent Risk Factors for Contrast-Induced Nephropathy After Cardiac Catheterization"},{"@value":"Why Is Proteinuria an Independent Risk Factor for Contrast-Induced Nephropathy?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282752372831360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guideline on the Use of Iodinated Contrast Media in Patients With Kidney Disease 2018"},{"@value":"JCS GUIDELINES : Guideline on the Use of Iodinated Contrast Media in Patients With Kidney Disease 2018"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942143993216","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines on the use of iodinated contrast media in patients with kidney disease 2012 : digest version"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000151772"},{"@type":"CROSSREF","@value":"10.1111/ctr.12715_references_DOI_UI0EeluoJn7tyULlxlQg8IXcs3i"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-19-0783_references_DOI_UI0EeluoJn7tyULlxlQg8IXcs3i"},{"@type":"CROSSREF","@value":"10.1007/s11604-019-00850-2_references_DOI_UI0EeluoJn7tyULlxlQg8IXcs3i"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-14-1345_references_DOI_UI0EeluoJn7tyULlxlQg8IXcs3i"},{"@type":"CROSSREF","@value":"10.2302/kjm.2015-0013-ir_references_DOI_UI0EeluoJn7tyULlxlQg8IXcs3i"},{"@type":"CROSSREF","@value":"10.1007/s11604-013-0226-4_references_DOI_UI0EeluoJn7tyULlxlQg8IXcs3i"}]}