{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137045978720896.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1146/annurev-immunol-032712-095912"}},{"identifier":{"@type":"URI","@value":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-032712-095912"}}],"dc:title":[{"@value":"The Adaptable Major Histocompatibility Complex (MHC) Fold: Structure and Function of Nonclassical and MHC Class I–Like Molecules"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The MHC fold is found in proteins that have a range of functions in the maintenance of an organism's health, from immune regulation to fat metabolism. Well adapted for antigen presentation, as seen for peptides in the classical MHC molecules and for lipids in CD1 molecules, the MHC fold has also been modified to perform Fc-receptor activity (e.g., FcRn) and for roles in host homeostasis (e.g., with HFE and ZAG). The more divergent MHC-like molecules, such as some of those that interact with the NKG2D receptor, represent the minimal MHC fold, doing away with the α3 domain and β<jats:sub>2</jats:sub>m while maintaining the α1/α2 platform domain for receptor engagement. Viruses have also co-opted the MHC fold for immune-evasive functions. The variations on the theme of a β-sheet topped by two semiparallel α-helices are discussed in this review, highlighting the fantastic adaptability of this fold for good and for bad.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137045978720897","@type":"Researcher","foaf:name":[{"@value":"Erin J. Adams"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry and Molecular Biology,"},{"@value":"Committee on Immunology, University of Chicago, Chicago, Illinois 60637;,"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137045978720896","@type":"Researcher","foaf:name":[{"@value":"Adrienne M. Luoma"}],"jpcoar:affiliationName":[{"@value":"Committee on Immunology, University of Chicago, Chicago, Illinois 60637;,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07320582"},{"@type":"EISSN","@value":"15453278"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/07320582"}],"prism:publicationName":[{"@value":"Annual Review of Immunology"}],"dc:publisher":[{"@value":"Annual Reviews"}],"prism:publicationDate":"2013-03-21","prism:volume":"31","prism:number":"1","prism:startingPage":"529","prism:endingPage":"561"},"reviewed":"false","url":[{"@id":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-032712-095912"}],"createdAt":"2013-01-09","modifiedAt":"2023-06-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218988616448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A comprehensive analysis of teleost MHC class I sequences"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235534106880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Comparative genomics of the <scp>NKG</scp>2D ligand gene family"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237895806208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Family of Nonclassical Class I MHC Genes Contributes to Ultrasensitive Chemodetection by Mouse Vomeronasal Sensory Neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709539574016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genome-wide SNP identification for the construction of a high-resolution genetic map of Japanese flounder (Paralichthys olivaceus): applications to QTL mapping of Vibrio anguillarum disease resistance and comparative genomic analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181955748096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prediction of intracellular targets of a small compound by analyzing peptides presented on MHC class I"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1146/annurev-immunol-032712-095912"},{"@type":"CROSSREF","@value":"10.1186/s12862-015-0309-1_references_DOI_7z3a364HH5vr89nxFb7DlDRDAjE"},{"@type":"CROSSREF","@value":"10.1111/imr.12320_references_DOI_7z3a364HH5vr89nxFb7DlDRDAjE"},{"@type":"CROSSREF","@value":"10.1093/dnares/dsv001_references_DOI_7z3a364HH5vr89nxFb7DlDRDAjE"},{"@type":"CROSSREF","@value":"10.1523/jneurosci.0186-14.2014_references_DOI_7z3a364HH5vr89nxFb7DlDRDAjE"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2018.11.089_references_DOI_7z3a364HH5vr89nxFb7DlDRDAjE"}]}