Effects of New Polymer‐Coated Extracorporeal Circuits on Biocompatibility During Cardiopulmonary Bypass

DOI Web Site Web Site 17 Citations

Bibliographic Information

Published
2000-07
Rights Information
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1046/j.1525-1594.2000.06520.x
Publisher
Wiley

Search this article

Description

<jats:p><jats:bold>Abstract:</jats:bold> An inflammatory response due to bioincompatibility of extracorporeal circuits is a major clinical issue during cardiopulmonary bypass (CPB). By using a swine model, we determined whether new polymer‐coated circuits, the blood‐contacting surfaces of which are coated with poly(2‐methoxyethylacrylate) (PMEA), would reduce the inflammatory response during CPB. Plasma bradykinin levels and the percentages of CD35‐positive monocytes in PMEA‐coated circuits were significantly lower than those in uncoated circuits during CPB. The amount of proteins adsorbed on the PMEA‐coated circuits was significantly lower than that on the uncoated circuits (0.30 μg/cm<jats:sup>2</jats:sup> versus 3.42 μg/ cm<jats:sup>2</jats:sup>). Almost no IgG, IgM, or C3c/d was detected in proteins adsorbed on the PMEA‐coated circuits although these proteins were clearly detected in proteins adsorbed on the uncoated circuits. We concluded that PMEA coating could reduce complement activation during CPB by suppressing the adsorption of IgG and IgM, which activate C3 via the classical pathway, on the surface of the circuits.</jats:p>

Journal

Citations (17)*help

See more

Details 詳細情報について

Report a problem

Back to top