{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137046071701504.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/cancers12071959"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2072-6694/12/7/1959/pdf"}}],"dc:title":[{"@value":"Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Cancer is one of the most common causes of disease-related deaths worldwide. Despite the discovery of many chemotherapeutic drugs that inhibit uncontrolled cell division processes for the treatment of various cancers, serious side effects of these drugs are a crucial disadvantage. In addition, multi-drug resistance is another important problem in anticancer treatment. Due to problems such as cytotoxicity and drug resistance, many investigations are being conducted to discover and develop effective anticancer drugs. In recent years, researchers have focused on the anticancer activity coumarins, due to their high biological activity and low toxicity. Coumarins are commonly used in the treatment of prostate cancer, renal cell carcinoma and leukemia, and they also have the ability to counteract the side effects caused by radiotherapy. Both natural and synthetic coumarin derivatives draw attention due to their photochemotherapy and therapeutic applications in cancer. In this review, a compilation of various research reports on coumarins with anticancer activity and investigation and a review of structure-activity relationship studies on coumarin core are presented. Determination of important structural features around the coumarin core may help researchers to design and develop new analogues with a strong anticancer effect and reduce the potential side effects of existing therapeutics.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137046071701504","@type":"Researcher","foaf:name":[{"@value":"Esra Küpeli Akkol"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046071701507","@type":"Researcher","foaf:name":[{"@value":"Yasin Genç"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Sıhhiye 06100, Ankara, Turkey"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046071701508","@type":"Researcher","foaf:name":[{"@value":"Büşra Karpuz"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046071701505","@type":"Researcher","foaf:name":[{"@value":"Eduardo Sobarzo-Sánchez"}],"jpcoar:affiliationName":[{"@value":"Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, 8330507 Santiago, Chile"},{"@value":"Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046071701506","@type":"Researcher","foaf:name":[{"@value":"Raffaele Capasso"}],"jpcoar:affiliationName":[{"@value":"Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici (Naples), Italy"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20726694"}],"prism:publicationName":[{"@value":"Cancers"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2020-07-19","prism:volume":"12","prism:number":"7","prism:startingPage":"1959"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2072-6694/12/7/1959/pdf"}],"createdAt":"2020-07-21","modifiedAt":"2025-10-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360572092803258496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diversity of Chemical Structures and Biosynthesis of Polyphenols in Nut-Bearing Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580229835996672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/cancers12071959"},{"@type":"CROSSREF","@value":"10.3389/fpls.2021.642581_references_DOI_Jt5Mw261rGt8S2hkLPjSjzDRljq"},{"@type":"CROSSREF","@value":"10.3390/ph16020231_references_DOI_Jt5Mw261rGt8S2hkLPjSjzDRljq"}]}