{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137046320663296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bmc.2009.01.070"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0968089609001138?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0968089609001138?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"19231204"}}],"dc:title":[{"@value":"Facile synthesis of diazido-functionalized biaryl compounds as radioisotope-free photoaffinity probes by Suzuki–Miyaura coupling"}],"description":[{"notation":[{"@value":"Suzuki-Miyaura coupling of 3-azido-5-(azidomethyl)phenylboronic acid pinacol ester with various aryl bromides affords corresponding diazido-functionalized biaryl compounds in good yields. This approach provides an easy access to radioisotope-free photoaffinity probes possessing biaryl structure. By using this method, we prepared a novel diazido-functionalized dantrolene analog, which showed selective inhibitory effect on physiological Ca(2+) release (PCR) from sarcoplasmic reticulum (SR) in mouse skeletal muscle without affecting Ca(2+)-induced Ca(2+) release (CICR)."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137046320663297","@type":"Researcher","foaf:name":[{"@value":"Takamitsu Hosoya"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046320663298","@type":"Researcher","foaf:name":[{"@value":"Atsushi Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046320663168","@type":"Researcher","foaf:name":[{"@value":"Toshiyuki Hiramatsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046320663300","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Aoyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046320663299","@type":"Researcher","foaf:name":[{"@value":"Takaaki Ikemoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046320663296","@type":"Researcher","foaf:name":[{"@value":"Masaaki Suzuki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09680896"}],"prism:publicationName":[{"@value":"Bioorganic & Medicinal Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2009-03","prism:volume":"17","prism:number":"6","prism:startingPage":"2490","prism:endingPage":"2496"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0968089609001138?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0968089609001138?httpAccept=text/plain"}],"createdAt":"2009-02-10","modifiedAt":"2025-10-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Radioisotopes","dc:title":"Radioisotopes"},{"@id":"https://cir.nii.ac.jp/all?q=Azides","dc:title":"Azides"},{"@id":"https://cir.nii.ac.jp/all?q=Spectrometry,%20Mass,%20Electrospray%20Ionization","dc:title":"Spectrometry, Mass, Electrospray Ionization"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Spectroscopy","dc:title":"Magnetic Resonance Spectroscopy"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium","dc:title":"Calcium"},{"@id":"https://cir.nii.ac.jp/all?q=Photoaffinity%20Labels","dc:title":"Photoaffinity Labels"},{"@id":"https://cir.nii.ac.jp/all?q=Spectrometry,%20Mass,%20Fast%20Atom%20Bombardment","dc:title":"Spectrometry, Mass, Fast Atom Bombardment"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230102011904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Formal C–H‐Azidation – Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708601192576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Convergent synthesis of trifunctional molecules by three sequential azido-type-selective 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