{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137046367152256.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.6261330"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.6261330"}}],"dc:title":[{"@value":"Stress-Induced Analgesia in Humans: Endogenous Opioids and Naloxone-Reversible Depression of Pain Reflexes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. The data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137046367152258","@type":"Researcher","foaf:name":[{"@value":"Jean Claude Willer"}],"jpcoar:affiliationName":[{"@value":"Laboratoire de Physiologie, Faculté de Médecine Saint-Antoine, 27 Rue Chaligny F75571 Paris Cedex 12, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046367152256","@type":"Researcher","foaf:name":[{"@value":"Henri Dehen"}],"jpcoar:affiliationName":[{"@value":"Clinique Neurologique, Hôpital Beaujon, 92110 Clichy, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046367152257","@type":"Researcher","foaf:name":[{"@value":"Jean Cambier"}],"jpcoar:affiliationName":[{"@value":"Clinique Neurologique, Hôpital Beaujon, 92110 Clichy, France"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"1981-05-08","prism:volume":"212","prism:number":"4495","prism:startingPage":"689","prism:endingPage":"691"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.6261330"}],"createdAt":"2006-10-05","modifiedAt":"2024-01-14","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285711725484544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of repeated tooth pulp stimulation on concentrations of plasma catecholamines, corticosterone, and glucose in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664367043200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.6261330"},{"@type":"CROSSREF","@value":"10.1179/1743132813y.0000000313_references_DOI_DXcSHf3MiD1qpRmyvrUpcGpQPrz"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2017.00276_references_DOI_DXcSHf3MiD1qpRmyvrUpcGpQPrz"}]}