{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137046431371264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1089/ars.2006.8.985"}},{"identifier":{"@type":"URI","@value":"http://www.liebertpub.com/doi/pdf/10.1089/ars.2006.8.985"}},{"identifier":{"@type":"PMID","@value":"16771688"}},{"identifier":{"@type":"NAID","@value":"30018295511"}}],"dc:title":[{"@value":"Urinary 8-Hydroxyguanine May Be a Better Marker of Oxidative Stress Than 8-Hydroxydeoxyguanosine in Relation to the Life Spans of Various Species"}],"description":[{"notation":[{"@value":"Oxidative DNA damage is believed to be involved in the aging process. Species with shorter potential life spans generally have a higher specific metabolic rate (SMR), and would be expected to have increased levels of oxidative stress and DNA damage, as compared to long-lived species. An automatized HPLC method based on electrochemical detection was used to measure the levels of the oxidative DNA damage markers 8-hydroxydeoxyguanosine (8-OH-dG) and 8-hydroxyguanine (8-OH-Gua) in urinary samples from mammals with various potential life spans (mice, rats, guinea pigs, cats, chimpanzees, and humans). There was no significant linear correlation (r = -0.71, p = 0.11) between the species' potential life spans (log transformed) and the urinary levels of 8-OH-dG as normalized to creatinine (8-OH-dG/creatinine), although the species with longer life spans, such as chimpanzee and human, had among the lowest levels detected. In contrast, the negative linear correlation between the species' potential life span (log transformed) and the urinary levels of 8-OH-Gua as normalized to creatinine (8-OH-Gua/creatinine), was significant (r = -0.97, p = 0.002). In addition, there was a positive linear and significant correlation between SMR and 8-OH-dG/creatinine (r = 0.91, p = 0.01) or 8- OH-Gua/creatinine (r = 0.90, p = 0.01). These results suggest that 8-OH-Gua, rather than 8-OH-dG, may be a more general marker for oxidative damage."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381137046431371268","@type":"Researcher","foaf:name":[{"@value":"Peter Svoboda"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046431371265","@type":"Researcher","foaf:name":[{"@value":"Muneyuki Maekawa"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046431371264","@type":"Researcher","foaf:name":[{"@value":"Kazuaki Kawai"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046431371269","@type":"Researcher","foaf:name":[{"@value":"Toshikazu Tominaga"}],"jpcoar:affiliationName":[{"@value":"Kumamoto Primates Research Park, Sanwa Kagaku Kenkyusho Co. Ltd., Kumamoto, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046431371266","@type":"Researcher","foaf:name":[{"@value":"Kirsti Savela"}],"jpcoar:affiliationName":[{"@value":"Finnish Institute of Occupational Health, Helsinki, Finland."}]},{"@id":"https://cir.nii.ac.jp/crid/1381137046431371267","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Kasai"}],"jpcoar:affiliationName":[{"@value":"Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15230864"},{"@type":"EISSN","@value":"15577716"}],"prism:publicationName":[{"@value":"Antioxidants & Redox Signaling"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2006-05","prism:volume":"8","prism:number":"5-6","prism:startingPage":"985","prism:endingPage":"992"},"reviewed":"false","url":[{"@id":"http://www.liebertpub.com/doi/pdf/10.1089/ars.2006.8.985"}],"createdAt":"2006-06-13","modifiedAt":"2026-02-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Guanine","dc:title":"Guanine"},{"@id":"https://cir.nii.ac.jp/all?q=Pan%20troglodytes","dc:title":"Pan troglodytes"},{"@id":"https://cir.nii.ac.jp/all?q=Guinea%20Pigs","dc:title":"Guinea Pigs"},{"@id":"https://cir.nii.ac.jp/all?q=Statistics%20as%20Topic","dc:title":"Statistics as Topic"},{"@id":"https://cir.nii.ac.jp/all?q=Deoxyguanosine","dc:title":"Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Life%20Expectancy","dc:title":"Life Expectancy"},{"@id":"https://cir.nii.ac.jp/all?q=8-Hydroxy-2'-Deoxyguanosine","dc:title":"8-Hydroxy-2'-Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=Cats","dc:title":"Cats"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Damage","dc:title":"DNA Damage"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204455847168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Urinary Excretion of an Oxidative Stress Marker, 8-hydroxyguanine (8-OH-Gua), among Nickel-cadmium Battery Workers"},{"@value":"Urinary Excretion of an Oxidative Stress Marker, 8‐hydroxyguanine (8‐OH‐Gua), among Nickel‐cadmium Battery Workers"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205085420288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"8-Hydroxyguanine in Urine and Serum as an Oxidative Stress Marker: Effects of Diabetes and Aging"},{"@language":"ja","@value":"酸化ストレスマーカーとしての尿中ならびに血清中の8-ヒドロキシグアニン：糖尿病ならびに加齢の影響"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205257146240","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Accurate Measurement of 8-OH-dG and 8-OH-Gua in Mouse DNA, Urine and Serum: Effects of X-ray Irradiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390565134813781632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Salivary 8-hydroxyguanine as a lifestyle-related oxidative stress biomarker in workers"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317012844416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Measurement of 8-hydroxyguanine as an oxidative stress biomarker in saliva by HPLC-ECD"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1089/ars.2006.8.985"},{"@type":"CIA","@value":"30018295511"},{"@type":"OPENAIRE","@value":"doi_dedup___::3a26432b708a8f4ee2863bb7b5b7319a"},{"@type":"CROSSREF","@value":"10.3164/jcbn.19-72_references_DOI_WITNXougBhoAbT2whx8YZ9JPetr"},{"@type":"CROSSREF","@value":"10.7888/juoeh.35.119_references_DOI_WITNXougBhoAbT2whx8YZ9JPetr"},{"@type":"CROSSREF","@value":"10.1186/s41021-018-0095-2_references_DOI_WITNXougBhoAbT2whx8YZ9JPetr"},{"@type":"CROSSREF","@value":"10.3123/jemsge.29.107_references_DOI_WITNXougBhoAbT2whx8YZ9JPetr"},{"@type":"CROSSREF","@value":"10.1539/joh.l7125_references_DOI_WITNXougBhoAbT2whx8YZ9JPetr"}]}