{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361137046545652608.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.081089398"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.081089398"}},{"identifier":{"@type":"PMID","@value":"11296258"}},{"identifier":{"@type":"NAID","@value":"30016222817"}}],"dc:title":[{"@value":"Functional disorders of the sympathetic nervous system in mice lacking the α\n            <sub>1B</sub>\n            subunit (Ca\n            <sub>v</sub>\n            2.2) of N-type calcium channels"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            N-type voltage-dependent Ca\n            <jats:sup>2+</jats:sup>\n            channels (VDCCs),\n predominantly localized in the nervous system, have been considered to\n play an essential role in a variety of neuronal functions, including\n neurotransmitter release at sympathetic nerve terminals. As a direct\n approach to elucidating the physiological significance of N-type VDCCs,\n we have generated mice genetically deficient in the α\n            <jats:sub>1B</jats:sub>\n            subunit (Ca\n            <jats:sub>v</jats:sub>\n            2.2). The α\n            <jats:sub>1B</jats:sub>\n            -deficient null\n mice, surprisingly, have a normal life span and are free from apparent\n behavioral defects. A complete and selective elimination of N-type\n currents, sensitive to ω-conotoxin GVIA, was observed without\n significant changes in the activity of other VDCC types in neuronal\n preparations of mutant mice. The baroreflex response, mediated by the\n sympathetic nervous system, was markedly reduced after bilateral\n carotid occlusion. In isolated left atria prepared from\n N-type-deficient mice, the positive inotropic responses to electrical\n sympathetic neuronal stimulation were dramatically decreased compared\n with those of normal mice. In contrast, parasympathetic nervous\n activity in the mutant mice was nearly identical to that of wild-type\n mice. Interestingly, the mutant mice showed sustained elevation of\n heart rate and blood pressure. These results provide direct evidence\n that N-type VDCCs are indispensable for the function of the sympathetic\n nervous system in circulatory regulation and indicate that N-type\n VDCC-deficient mice will be a useful model for studying disorders\n attributable to sympathetic nerve dysfunction.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380013247121507471","@type":"Researcher","foaf:name":[{"@value":"Mitsuhiro Ino"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507460","@type":"Researcher","foaf:name":[{"@value":"Takashi Yoshinaga"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507457","@type":"Researcher","foaf:name":[{"@value":"Minoru Wakamori"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507459","@type":"Researcher","foaf:name":[{"@value":"Norimasa Miyamoto"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507461","@type":"Researcher","foaf:name":[{"@value":"Eiki Takahashi"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507469","@type":"Researcher","foaf:name":[{"@value":"Jiro Sonoda"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507462","@type":"Researcher","foaf:name":[{"@value":"Takaki Kagaya"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507470","@type":"Researcher","foaf:name":[{"@value":"Tohru Oki"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507463","@type":"Researcher","foaf:name":[{"@value":"Takeshi Nagasu"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507468","@type":"Researcher","foaf:name":[{"@value":"Yukio Nishizawa"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507472","@type":"Researcher","foaf:name":[{"@value":"Isao Tanaka"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507473","@type":"Researcher","foaf:name":[{"@value":"Keiji Imoto"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507458","@type":"Researcher","foaf:name":[{"@value":"Shinichi Aizawa"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507466","@type":"Researcher","foaf:name":[{"@value":"Sheryl Koch"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507464","@type":"Researcher","foaf:name":[{"@value":"Arnold Schwartz"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507456","@type":"Researcher","foaf:name":[{"@value":"Tetsuhiro Niidome"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507465","@type":"Researcher","foaf:name":[{"@value":"Kohei Sawada"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380013247121507467","@type":"Researcher","foaf:name":[{"@value":"Yasuo Mori"}],"jpcoar:affiliationName":[{"@value":"Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba,\r Ibaraki 300-2635, Japan; Department of Information\r Physiology, National Institute for Physiological Sciences, Myodaiji,\r Okazaki, Aichi 444-8585, Japan; Department of\r Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto\r University, Kumamoto University School of Medicine, 2-2-1, Honjo,\r Kumamoto 860, Japan; and Institute of Molecular\r Pharmacology and Biophysics, University of Cincinnati, College of\r Medicine,..."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2001-04-10","prism:volume":"98","prism:number":"9","prism:startingPage":"5323","prism:endingPage":"5328"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.081089398"}],"createdAt":"2002-07-26","modifiedAt":"2022-04-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Sympathetic%20Nervous%20System","dc:title":"Sympathetic Nervous System"},{"@id":"https://cir.nii.ac.jp/all?q=Electric%20Conductivity","dc:title":"Electric Conductivity"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Pressure","dc:title":"Blood Pressure"},{"@id":"https://cir.nii.ac.jp/all?q=Superior%20Cervical%20Ganglion","dc:title":"Superior Cervical Ganglion"},{"@id":"https://cir.nii.ac.jp/all?q=Baroreflex","dc:title":"Baroreflex"},{"@id":"https://cir.nii.ac.jp/all?q=Myocardial%20Contraction","dc:title":"Myocardial Contraction"},{"@id":"https://cir.nii.ac.jp/all?q=Electric%20Stimulation","dc:title":"Electric Stimulation"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Subunits","dc:title":"Protein Subunits"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium%20Channels,%20N-Type","dc:title":"Calcium Channels, N-Type"},{"@id":"https://cir.nii.ac.jp/all?q=Carotid%20Arteries","dc:title":"Carotid Arteries"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Rate","dc:title":"Heart Rate"},{"@id":"https://cir.nii.ac.jp/all?q=omega-Conotoxin%20GVIA","dc:title":"omega-Conotoxin GVIA"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium","dc:title":"Calcium"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Atria","dc:title":"Heart Atria"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Deletion","dc:title":"Gene Deletion"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335835604608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure"}]},{"@id":"https://cir.nii.ac.jp/crid/1050013397240361344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Calcium channel blocker in patients with chronic kidney disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810792963968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The organ-protective effect of N-type Ca(2+) channel blockade."}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285766893056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of N-type Ca[2+] channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure."}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232000746368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643784528512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced β-adrenergic response in mice with dominant-negative expression of the PKD2L1 channel"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905603459200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular mechanisms of mammalian sperm capacitation, and its regulation by sodium‐dependent secondary active transporters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167343285120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The G-protein–gated K+ channel, <i>IKACh</i>, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588379369486080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656930123520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Decreased calcium channel currents and facilitated epinephrine release in the Ca2+ channel β3 subunit-null mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658906455936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"N-type Calcium Channel in the Pathogenesis of Experimental Autoimmune Encephalomyelitis*"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660889185024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707384126336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975844329764096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"An N-/L-type calcium channel blocker, cilnidipine, suppresses autonomic, electrical, and structural remodelling associated with atrial fibrillation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204624978816","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Suppression of Formalin-Induced Nociception by Cilnidipine, a Voltage-Dependent Calcium Channel Blocker"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205043265152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pattern of Compensatory Expression of Voltage-Dependent Ca2+ Channel .ALPHA.1 and .BETA. Subunits in Brain of N-type Ca2+ Channel .ALPHA.1B Subunit Gene-Deficient Mice with a CBA/JN Genetic Background"},{"@value":"Pattern of Compensatory Expression of Voltage-Dependent Ca〔2+〕 Channel α1 and β Subunits in Brain of N-type Ca〔2+〕 Channel α1B Subunit Gene-Deficient Mice with a CBA/JN Genetic Background"},{"@language":"ja-Kana","@value":"Pattern of Compensatory Expression of Voltage Dependent Ca 2 Channel アルファ 1 and ベータ Subunits in Brain of N type Ca 2 Channel アルファ 1B Subunit Gene Deficient Mice with a CBA JN Genetic Background"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649918295168","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of ablation of N- and R-type Ca^<2+> channels on pain transmission"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.081089398"},{"@type":"CIA","@value":"30016222817"},{"@type":"OPENAIRE","@value":"doi_dedup___::f2be576e4390f1f2fcdac3fe2363865b"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2013.03.040_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1007/s10157-021-02153-1_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1093/cvr/cvu185_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1248/bpb.32.1695_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2010.01.036_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1016/j.pharmthera.2015.02.001_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0261668_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1002/rmb2.12614_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1085/jgp.201310996_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1038/srep27192_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1111/bph.16487_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1074/jbc.m109.089805_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1126/scisignal.aat5185_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1538/expanim.54.29_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1007/978-3-031-08881-0_11_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"},{"@type":"CROSSREF","@value":"10.1093/cvr/cvz136_references_DOI_M6wD3TVb4tCskwlOkR5j7a4I2nh"}]}