{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361412891701517184.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ejphar.2020.172940"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0014299920300327?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0014299920300327?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"31968212"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"JAK-STAT-dependent regulation of scavenger receptors in LPS-activated murine macrophages"}],"description":[{"notation":[{"@value":"In atherosclerosis progression, atherosclerotic plaques develop upon accumulated foam cells derived from macrophages that take up modified low-density lipoprotein (LDL). CD36 and CD204 are the principal scavenger receptors responsible for the uptake of modified LDL. Lipopolysaccharide (LPS) exacerbates atherosclerosis by enhancing the expression of scavenger receptors and thus increasing the uptake of modified LDL into macrophages. However, the signaling pathways that mediate LPS and scavenger receptor expression have not been fully elucidated. We used mouse bone marrow-derived macrophages and investigated the effects of LPS in vitro. LPS enhanced the phosphorylation of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription-1 (STAT-1). Inhibitors of the mitogen-activated protein kinase (MAPK)/ERK kinase (MEK) pathway (U0126 and PD0325901) suppressed the uptake of acetylated-LDL (Ac-LDL) and the expression of CD204 but not CD36 in LPS-activated macrophages. Inhibitors of the Janus tyrosine kinase (JAK)-STAT pathway (ruxolitinib and tofacitinib) suppressed the uptake of Ac-LDL and the expression of both CD36 and CD204 in LPS-activated macrophages. We next injected LPS into the peritoneal cavity of mice and analyzed the effects of LPS. MEK inhibitor U0126 suppressed the uptake of Ac-LDL and the expression of CD204 but not CD36 in LPS-activated macrophages. JAK inhibitor ruxolitinib suppressed the uptake of Ac-LDL and the expression of both CD36 and CD204 in LPS-activated macrophages. These results suggest that scavenger receptors in LPS-activated mouse macrophages are regulated through a JAK-STAT-dependent pathway. Although further evaluation is necessary, JAK-STAT inhibition could be useful in atherosclerosis therapy, at least for atherosclerosis exacerbated by LPS."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751164057728","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60433786"},{"@type":"NRID","@value":"1000060433786"},{"@type":"NRID","@value":"9000392137360"},{"@type":"NRID","@value":"9000006932756"},{"@type":"NRID","@value":"9000273023022"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hryota"}],"foaf:name":[{"@value":"Ryota Hashimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412891701517184","@type":"Researcher","foaf:name":[{"@value":"Ryo Kakigi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412891701517190","@type":"Researcher","foaf:name":[{"@value":"Yuki Miyamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412891701517186","@type":"Researcher","foaf:name":[{"@value":"Kyoko Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412891701517187","@type":"Researcher","foaf:name":[{"@value":"Seigo Itoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412891701517185","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Daida"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412891701517188","@type":"Researcher","foaf:name":[{"@value":"Takao Okada"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801192480256","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00231259"},{"@type":"NRID","@value":"1000000231259"},{"@type":"NRID","@value":"9000392137361"},{"@type":"NRID","@value":"9000253225559"},{"@type":"NRID","@value":"9000404490768"},{"@type":"NRID","@value":"9000253226984"},{"@type":"NRID","@value":"9000021935596"},{"@type":"NRID","@value":"9000323296428"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/katoyo"}],"foaf:name":[{"@value":"Youichi Katoh"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00142999"}],"prism:publicationName":[{"@value":"European Journal of Pharmacology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2020-03","prism:volume":"871","prism:startingPage":"172940"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0014299920300327?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0014299920300327?httpAccept=text/plain"}],"createdAt":"2020-01-20","modifiedAt":"2025-09-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=CD36%20Antigens","dc:title":"CD36 Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Lipopolysaccharides","dc:title":"Lipopolysaccharides"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Scavenger","dc:title":"Receptors, Scavenger"},{"@id":"https://cir.nii.ac.jp/all?q=Scavenger%20Receptors,%20Class%20A","dc:title":"Scavenger Receptors, Class A"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophage%20Activation","dc:title":"Macrophage Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=STAT%20Transcription%20Factors","dc:title":"STAT Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphorylation","dc:title":"Phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=Extracellular%20Signal-Regulated%20MAP%20Kinases","dc:title":"Extracellular Signal-Regulated MAP Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Janus%20Kinases","dc:title":"Janus Kinases"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782005464832","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K17977"},{"@type":"JGN","@value":"JP18K17977"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K17977/"}],"notation":[{"@language":"ja","@value":"システインの過剰摂取は動脈硬化を悪化させるのか"},{"@language":"en","@value":"Does excessive cysteine intake exacerbate the atherosclerosis?"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256884551552","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K01836"},{"@type":"JGN","@value":"JP16K01836"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K01836/"}],"notation":[{"@language":"ja","@value":"骨髄間葉系幹細胞の多分化能を応用した再生血管の耐圧・耐久化と骨髄脂肪変性の予防"},{"@language":"en","@value":"Phorbol 12‑myristate 13‑acetate (PMA) suppresses high  Ca2+‑enhanced adipogenesis in bone marrow stromal 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