{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361412895701023744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/pin.12868"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpin.12868"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pin.12868"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pin.12868"}},{"identifier":{"@type":"PMID","@value":"31691489"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Inflammation in myocardial disease: From myocarditis to dilated cardiomyopathy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Dilated cardiomyopathy (DCM) is a heterogeneous group of myocardial diseases clinically defined by the presence of left ventricular dilatation and contractile dysfunction. Among various causes of DCM, a progression from viral myocarditis to DCM has long been hypothesized. Supporting this possibility, studies by endomyocardial biopsy, the only method to obtain a definite diagnosis of myocarditis at present, have provided evidence of inflammation in the myocardium in DCM patients. A number of experimental studies have elucidated a cell‐mediated autoimmune mechanism triggered by viral infection in the progression of myocarditis to DCM. In addition, the important role of inflammation in the pathogenesis of heart failure has been recognized, and many terms including myocarditis, inflammatory cardiomyopathy, and inflammatory DCM have been used for myocardial diseases associated with inflammation. This review discusses the pathophysiology of inflammation in the myocardium, and refers to diagnosis and treatment based on these concepts.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381412895701023872","@type":"Researcher","foaf:name":[{"@value":"Kyoko Imanaka‐Yoshida"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Matrix Biology Mie University Graduate School of Medicine  Mie Japan"},{"@value":"Mie University Research Center for Matrix Biology  Mie Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13205463"},{"@type":"EISSN","@value":"14401827"}],"prism:publicationName":[{"@value":"Pathology International"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-11-05","prism:volume":"70","prism:number":"1","prism:startingPage":"1","prism:endingPage":"11"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpin.12868"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pin.12868"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pin.12868"}],"createdAt":"2019-11-06","modifiedAt":"2023-09-07","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Cardiomyopathies","dc:title":"Cardiomyopathies"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782014691968","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H03442"},{"@type":"JGN","@value":"JP19H03442"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03442/"}],"notation":[{"@language":"ja","@value":"拡張型心筋症における慢性炎症の病態メカニズムの解明と層別化"},{"@language":"en","@value":"Elucidation of pathophysiological mechanism of chronic inflammation and risk stratification of dilated cardiomyopathy."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202618852864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tenascin‐C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation"},{"@value":"Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1050855422577186176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Guerin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-α"},{"@value":"A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette–Guèrin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-α"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217581187968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immune checkpoint inhibitor-related myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236845010688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142567028352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142615741568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immune cell infiltration landscapes in pediatric acute myocarditis analyzed by CIBERSORT"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144457209216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antiviral and myocyte protective effects of murine interferon-β and -α<sub>2</sub>in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145034376832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gamma-globulin treatment of acute myocarditis in the pediatric population."}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693708116864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tenascin-C May Accelerate Cardiac Fibrosis by Activating Macrophages via the Integrin αVβ3/Nuclear Factor–κB/Interleukin-6 Axis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285704874658944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Influenza‐associated septic shock accompanied by septic cardiomyopathy that developed in summer and mimicked fulminant myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710729913856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Matricellular Proteins: New Molecular Targets To Prevent Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618489965184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiac Autoimmunity: Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618780188416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TNF‐α signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF‐α receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619226072320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"When the heart gets the flu"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620215808512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620565891456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Randomized, Placebo-Controlled Study for Immunosuppressive Treatment of Inflammatory Dilated Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620615040256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory Cardiomyopathic Syndromes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620708618112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621150447488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dilated Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621529016576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of titin in cardiomyopathy: from DNA variants to patient stratification"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643765303424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tenascin-C in Heart Diseases—The Role of Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306904385857280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cardiovascular magnetic resonance radiologic-pathologic correlation in radiomic analysis of myocardium in non-ischemic dilated cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164489352960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Significance of Myocardial Tenascin-C Expression in Left Ventricular Remodelling and Long-Term Outcome in Patients with Dilated Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183397590272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophages in age-related chronic inflammatory diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093825971072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093867253888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Innate Immunity and the Failing Heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094257686400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiac fibroblasts support cardiac inflammation in heart failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094649340416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diagnosis of Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094724337664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095768781568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamic Expression of Tenascin-C After Myocardial Ischemia and Reperfusion: Assessment by <sup>125</sup>I-Anti–Tenascin-C Antibody Imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341825931520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tenascin-C as a potential marker for immunohistopathology of doxorubicin-induced cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655025331840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Impact of the Presence of Macrophages in Endomyocardial Biopsies of Patients with Dilated Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660745145600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The pathological implications of heart transplantation: Experience with 50 cases in a single center"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568650509568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-6 receptor inhibition modulates the immune reaction and restores titin phosphorylation in experimental myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568662142464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570498832640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570887091072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of Intrinsic and Extrinsic Proapoptotic Signaling Pathways in Interleukin-18-mediated Human Cardiac Endothelial Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571463915904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted Anticytokine Therapy in Patients With Chronic Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593692059008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical significance of chronic myocarditis: systematic review and meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857612615483264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Pathogenesis of Cardiac Fibrosis: A Review of Recent Progress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861295470640128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of T Lymphocytes in the Pathogenesis of Coxsackie Virus B3 Heart Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044728302208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Controlled Trial of Intravenous Immune Globulin in Recent-Onset Dilated Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045848969216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Eosinophils in Autoimmune Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518505477376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TNF‐α induces TGF‐β<sub>1</sub> expression in lung fibroblasts at the transcriptional level <i>via</i> AP‐1 activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519046083712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lymphocytic active myocarditis characterized by numerous clusters of lymphocytes: A chronic variant of myocarditis?"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519251811328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Innate Immune System in Chronic Cardiomyopathy: A European Society of Cardiology (Esc) Scientific Statement from the Working Group on Myocardial Function of the ESC"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519273514368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520384844928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytokines and Cytokine Receptors in Advanced Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520944959488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophage diversity in cardiac inflammation: A review"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521075920512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"From Myocarditis to Cardiomyopathy: Mechanisms of Inflammation and Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993689029760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-κB pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994392136960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intravenous Immune Globulin in the Therapy of Myocarditis and Acute Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994580403840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viral myocarditis—diagnosis, treatment options, and current controversies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995252321792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Learning from myocarditis: mimicry, chaos and black holes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995845049472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995895269248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dilated cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996166228992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468393481088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468884951936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interferon-β Treatment Eliminates Cardiotropic Viruses and Improves Left Ventricular Function in Patients With Myocardial Persistence of Viral Genomes and Left Ventricular Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469023906688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469276393216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural killer cells in inflammatory heart disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469554407168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunosuppressive Therapy for Active Lymphocytic Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471168746624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viral myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471315156480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943994075520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diagnostic utility of tenascin‐C for evaluation of the activity of human acute myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944699503488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Persistent left ventricular dysfunction after acute lymphocytic myocarditis: Frequency and predictors"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945514267776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Prospective, Randomized, Controlled Trial of Prednisone for Dilated Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945838485888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Classic Interleukin-6 Receptor Signaling and Interleukin-6 trans-Signaling Differentially Control Angiotensin II-Dependent Hypertension, Cardiac Signal Transducer and Activator of Transcription-3 Activation, and Vascular Hypertrophy in Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419491683328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420107472256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421178112768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (Nonfulminant) Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421202775424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894199165696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894714850176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinicopathoiogic description of myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895020551296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Results of Targeted Anti–Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895289174400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viral Persistence in the Myocardium Is Associated With Progressive Cardiac Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895720123392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cross-Regulation of T Regulatory—Cell Response after Coxsackievirus B3 Infection by NKT and γδ T Cells in the Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896303427712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor Necrosis Factor-α Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369009164288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A nonsteroid anti-inflammatory drug exacerbates coxsackie B3 murine myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369712016768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recent advances in the management of autoimmune myocarditis: insights from animal studies."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369718565632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Basic mechanisms in heart failure: The cytokine hypothesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369898691712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Negative selection, epitope mimicry and autoimmunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370312970240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370486739840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T‐cell immunity in myocardial inflammation: pathogenic role and therapeutic manipulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370685197952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-1β Induces Tissue- and Cell Type–Specific Expression of Adhesion Molecules In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370981858304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"L-Selectin–Dependent Leukocyte Adhesion to Microvascular But Not to Macrovascular Endothelial Cells of the Human Coronary System"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843559816832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843675590144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical Cytokine Pathways to Cardiac Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844824316800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pressure-Mediated Hypertrophy and Mechanical Stretch Induces IL-1 Release and Subsequent IGF-1 Generation to Maintain Compensative Hypertrophy by Affecting Akt and JNK Pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844938042368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845265892736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical characteristics and long-term outcome of acute myocarditis in children"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845414893312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Incremental Prognostic Values of Serum Tenascin-C Levels With Blood B-type Natriuretic Peptide Testing at Discharge in Patients With Dilated Cardiomyopathy and Decompensated Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318317679232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor Necrosis Factor-α–Induced AT\n            <sub>1</sub>\n            Receptor Upregulation Enhances Angiotensin II–Mediated Cardiac Fibroblast Responses That Favor Fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319186044032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Eplerenone Attenuates Myocardial Fibrosis in the Angiotensin II-Induced Hypertensive Mouse: Involvement of Tenascin-C Induced by Aldosterone-Mediated Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319761791232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty: expression of tenascin C as a possible marker for inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320425216128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hepatitis C Virus from the Hearts of Patients with Myocarditis and Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320614744064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Heart Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321097005184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection of Experimental Autoimmune Myocarditis in Rats by\n            <sup>111</sup>\n            In Monoclonal Antibody Specific for Tenascin-C"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321224252160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Clinical Trial of Immunosuppressive Therapy for Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793303251072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammation – Cause or Consequence of Heart Failure or Both?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793586864512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794130341248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Myocarditis: A Clinical Overview"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794798246400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intravenous immunoglobulin therapy for patients with idiopathic cardiomyopathy and endomyocardial biopsy-proven high PVB19 viral load"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795095565952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795783766400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tenascin‐C is a useful marker for disease activity in myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796220614016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Treatment options in myocarditis and inflammatory cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268223143552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-21R expression on CD8+ T cells promotes CD8+ T cell activation in coxsackievirus B3 induced myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268426003072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chronic myocarditis with a long clinical course: Report of an autopsy case of probable autoimmune myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268847896448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High Prevalence of Viral Genomes and Multiple Viral Infections in the Myocardium of Adults With “Idiopathic” Left Ventricular Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269746331520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270066556416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271112805632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunosuppressive Therapy Improves Both Short- and Long-Term Prognosis in Patients With Virus-Negative Nonfulminant Inflammatory Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1371412895701023236","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Guideline for diagnosing chronic myocarditis. Japanese Circulation Society (JCS) Task Force Committee on chronic myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205102405120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205104950016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guidelines for Diagnosis and Treatment of Myocarditis (JCS 2009)"},{"@value":"Guidelines for diagnosis and treatment of myocarditis (JCS 2009): digest version"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205105637120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Post-Infarction Inflammation and Left Ventricular Remodeling"},{"@value":"Post-infarction inflammation and left ventricular remodeling: a double-edged sword"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205105848576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Higher Serum Tenascin-C Levels Reflect the Severity of Heart Failure, Left Ventricular Dysfunction and Remodeling in Patients With Dilated Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205225703424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Noninvasive Detection of Cardiac Repair After Acute Myocardial Infarction in Rats by 111In Fab Fragment of Monoclonal Antibody Specific for Tenascin-C"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205226722816","@type":"Article","resourceType":"letter","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Letter by Mezzaroma, <i>et al</i> Regarding Article, “NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction”"},{"@value":"NLRP3 Inflammasome as a Novel Player in Myocardial Infarction"},{"@value":"Reply to Letter Regarding Article, “NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction”"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206432023936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Histopathological findings of acute and convalescent myocarditis obtained by serial endomyocardial biopsy."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206434222336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of histopathologic findings in cases with dilated cardiomyopathy with special reference to formulating diagnostic criteria on the possibility of postmyocarditic change."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680080372864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tenascin-C in Cardiovascular Tissue Remodeling"},{"@value":"Tenascin-C in cardiovascular tissue remodeling: from development to inflammation and repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084897408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inflammatory Mechanisms of Cardiovascular Remodeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084922240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Early Prediction Model for Successful Bridge to Recovery in Patients With Fulminant Myocarditis Supported With Percutaneous Venoarterial Extracorporeal Membrane Oxygenation　― Insights From the CHANGE PUMP Study ―"},{"@value":"Early prediction model for successful bridge to recovery in patients with fulminant myocarditis supported with percutaneous venoarterial extracorporeal membrane oxygenation—insights from the CHANGE PUMP study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680201848704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fulminant Myocarditis With Prolonged Active Lymphocytic Infiltration After Hemodynamic Recovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681411007616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"On the interstitial fibrotic changes in acute and convalescent myocarditis obtained by serial endomyocardial biopsy."}]},{"@id":"https://cir.nii.ac.jp/crid/1390295879375868800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"JCS 2023 Guideline on the Diagnosis and Treatment of Myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390306981944780800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chronic Active Myocarditis and Inflammatory Cardiomyopathy　― Challenges in Diagnosis and Treatment ―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238072054016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C"}]},{"@id":"https://cir.nii.ac.jp/crid/1390573726308614272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acute Myocarditis with Severe Fever and Thrombocytopenia Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1390583723560677632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis and Biological Evaluation of Naproxen Derivatives as Novel NLRP3 Inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845712978619776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prognostic Value of Electrocardiography in Patients With Fulminant Myocarditis Supported by Percutaneous Venoarterial Extracorporeal Membrane Oxygenation　― Analysis From the CHANGE PUMP Study ―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390855455480590464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Myocardial T-Lymphocytes as a Prognostic Risk-Stratifying Marker of Dilated Cardiomyopathy　― Results of the Multicenter Registry to Investigate Inflammatory Cell Infiltration in Dilated Cardiomyopathy in Tissues of Endomyocardial Biopsy (INDICATE Study) ―"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499099963264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Myocarditis: a histopathologic definition and classification."}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975090004992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Activation of human macrophage by mechanical ventilation in vitro"},{"@value":"Activation of human macrophages by mechanical ventilation in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399000477440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical and pathologic features of chronic myocarditis: Four autopsy cases presenting as dilated cardiomyopathy in life."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/pin.12868"},{"@type":"KAKEN","@value":"PRODUCT-22978335"},{"@type":"OPENAIRE","@value":"doi_dedup___::d425fb1b60af967d0d468ed32a56e158"},{"@type":"CROSSREF","@value":"10.1152/ajpcell.00353.2020_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1016/j.jjcc.2020.08.004_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-22-0696_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.3390/ijms22115828_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.7018-21_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1016/j.jocmr.2025.101881_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.3390/ijms22020794_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1248/cpb.c24-00465_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1093/ehjopen/oead104_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1007/s00380-021-01914-y_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.3390/ijms23052617_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-21-0529_references_DOI_X13036wBspCewNwrN4356JVp7HS"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-25-0246_references_DOI_X13036wBspCewNwrN4356JVp7HS"}]}