{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418519461519488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1365-2826.2008.01734.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2826.2008.01734.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2826.2008.01734.x"}}],"dc:title":[{"@value":"Measurement of Immediate‐Early Gene Activation‐ <i>c‐fos</i> and Beyond"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Immediate‐early genes (IEG) are powerful tools for identifying activated neurosecretory neurones and extended circuits that affect neuroendocrine functions. The generally acknowledged scenario is when cells became activated, IEGs expressed and IEG‐encoded transcription factors affect target gene expression. However, there are several examples in which: (i) neuronal activation occurs without induction of IEGs; (ii) IEG induction is not related to challenge‐induced neuropeptide expression; and (iii) markers of neuronal activation are not expressed in chronically activated neurones. In spite of these limitations, the use of c‐Fos and other regulatory‐ or effector transcription factors as markers of neuronal activation will continue to be an extremely powerful technique. Recently‐developed models, including transgenic mice expressing different marker genes under the regulation of IEG promoters, will help to monitor neuronal activity <jats:italic>in vivo</jats:italic> or <jats:italic>ex vivo</jats:italic> and to reveal connection between activated neurones. Furthermore, combinations between novel imaging techniques, such as magnetic resonance and IEG‐based mapping strategies, will open new means with which to study functional activity in the neurosecretory systems.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004231173685257","@type":"Researcher","foaf:name":[{"@value":"K. J. Kovács"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09538194"},{"@type":"EISSN","@value":"13652826"}],"prism:publicationName":[{"@value":"Journal of Neuroendocrinology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2008-06","prism:volume":"20","prism:number":"6","prism:startingPage":"665","prism:endingPage":"672"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2826.2008.01734.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2826.2008.01734.x"}],"createdAt":"2008-06-18","modifiedAt":"2023-09-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050866040506590464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endogenous Androgens Diminish Food Intake and Activation of Orexin A Neurons in Response to Reduced Glucose Availability in Male Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216812183424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of Social Encounter-Induced Activation of Prefrontal Serotonergic Systems in the Abnormal Behaviors of Isolation-Reared Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219409114880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Detection of Neural Activity in the Brains of Japanese Honeybee Workers during the Formation of a “Hot Defensive Bee Ball”"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231173684992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231545157760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617811063040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617811285888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exercise and pharmacological inhibition of histone deacetylase improves cognitive function accompanied by an increase of gene expressions crucial for neuronal plasticity in the hippocampus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643780560000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuromedin U modulates neuronal excitability in rat hippocampal slices"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754846215936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865727333120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380141300608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Socially activated neurons in the anterior cingulate cortex are essential for social behavior in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643379979008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Single-cell bioluminescence imaging of deep tissue in freely moving animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655413799680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immunohistochemical Analysis of Fos Protein Expression for Exploring Brain Regions Related to Central Nervous System Disorders and Drug Actions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657328856704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660323324800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurogenesis Enhances Response Specificity to Spatial Pattern Stimulation in Hippocampal Cultures"}]},{"@id":"https://cir.nii.ac.jp/crid/1360849940719641344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593699461760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361978698493961472","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immediate Early Gene Expression in Brain Regions Associated with the Social Behavioral Network After Male Competition in Medaka Fish"}]},{"@id":"https://cir.nii.ac.jp/crid/1391975276374241792","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Continuous exposure to α-glycosyl isoquercitrin from developmental stages to          adulthood is necessary for facilitating fear extinction learning in rats"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1365-2826.2008.01734.x"},{"@type":"CROSSREF","@value":"10.1038/npp.2013.52_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0032902_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1007/s00213-016-4353-3_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1007/s12576-014-0312-0_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1016/j.neuroscience.2016.06.004_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1293/tox.2020-0025_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2020.147191_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1016/j.neulet.2021.135749_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1016/j.npep.2021.102168_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.3390/nu14061235_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1186/s13041-023-01020-2_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.3390/ijms231911739_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1109/tbme.2016.2639468_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2024.150251_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1126/science.aaq1067_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1007/978-1-4939-6490-1_17_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1007/s00213-020-05518-8_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.1186/s42238-021-00081-1_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"},{"@type":"CROSSREF","@value":"10.2108/zs200045_references_DOI_N4UzWq4gjYM5VCR4gCaPluf93uf"}]}