{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361418519649513344.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0014-2999(93)90717-v"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:001429999390717V?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:001429999390717V?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"8386092"}}],"dc:title":[{"@value":"Effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions in mice"}],"description":[{"notation":[{"@value":"The effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions was studied in mice. Thioperamide significantly and dose dependently decreased the duration of each phase of convulsion and raised the electroconvulsive threshold. Its anticonvulsant effects were prevented by pretreatment with (R)-alpha-methylhistamine, a histamine H3 receptor agonist. These findings suggest that the effect of thioperamide on electrically induced convulsions is due to an increase in endogenous histamine release in the brain, an effect mediated by histamine H3 receptors. The anticonvulsant effect of thioperamide was antagonized strongly by mepyramine (or pyrilamine), a centrally acting histamine H1 receptor antagonist, but not by zolantidine, a centrally acting histamine H2 receptor antagonist. Thus, the blockade by mepyramine of the thioperamide-induced decrease in seizure susceptibility indicates that histamine released by thioperamide from the histaminergic nerve terminals interacts with the histamine H1 receptors of postsynaptic neurons. These findings support the hypothesis that the central histaminergic system is involved in the inhibition of seizures."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381418519649513345","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Yokoyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418519649513346","@type":"Researcher","foaf:name":[{"@value":"Kenji Onodera"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418519649513344","@type":"Researcher","foaf:name":[{"@value":"Kazuie Iinuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1381418519649513347","@type":"Researcher","foaf:name":[{"@value":"Takehiko Watanabe"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00142999"}],"prism:publicationName":[{"@value":"European Journal of Pharmacology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1993-03","prism:volume":"234","prism:number":"1","prism:startingPage":"129","prism:endingPage":"133"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:001429999390717V?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:001429999390717V?httpAccept=text/plain"}],"createdAt":"2002-12-14","modifiedAt":"2019-04-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Electroshock","dc:title":"Electroshock"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine%20Antagonists","dc:title":"Histamine Antagonists"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20Strains","dc:title":"Mice, Inbred Strains"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Piperidines","dc:title":"Piperidines"},{"@id":"https://cir.nii.ac.jp/all?q=Seizures","dc:title":"Seizures"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Histamine","dc:title":"Receptors, Histamine"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Histamine%20H3","dc:title":"Receptors, Histamine H3"},{"@id":"https://cir.nii.ac.jp/all?q=Anticonvulsants","dc:title":"Anticonvulsants"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360283690800348800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204272611200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Towards Understanding Mechanisms of Drug Action and Functions of the Body on the Molecular Level. Studies on histamine with L-histidine decarboxylase, a histamine-forming enzyme, as a probe: from purification to gene knockout."},{"@language":"ja","@value":"薬の作用機序と生体機能の分子的理解に向けて　　ヒスタミンに関する研究　　ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@value":"ヒスタミンに関する研究:ヒスチジン脱炭酸酵素の精製から欠損マウスまで"},{"@language":"ja-Kana","@value":"ヒスタミン ニ カンスル ケンキュウ ヒスチジン ダツタンサン コウソ ノ セイセイ カラ ケッソン マウス マデ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204627115776","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Histamine H3 Receptor Antagonists Go to Clinics"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679261190912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Histamine H1-Receptors in the Anticonvulsive Effect of Morphine against Maximal Electroconvulsive Shock in Mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680151884032","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in Mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/0014-2999(93)90717-v"},{"@type":"OPENAIRE","@value":"doi_dedup___::1d9f57b44a49c210d4cf8a5c822d1253"},{"@type":"CROSSREF","@value":"10.1254/fpj.118.159_references_DOI_Ul12a2MYrFKa4DiZz8US4jsoVDT"},{"@type":"CROSSREF","@value":"10.1248/bpb.31.2163_references_DOI_Ul12a2MYrFKa4DiZz8US4jsoVDT"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2017.05.081_references_DOI_Ul12a2MYrFKa4DiZz8US4jsoVDT"},{"@type":"CROSSREF","@value":"10.1254/jphs.fp0061487_references_DOI_Ul12a2MYrFKa4DiZz8US4jsoVDT"},{"@type":"CROSSREF","@value":"10.1254/jjp.71.109_references_DOI_Ul12a2MYrFKa4DiZz8US4jsoVDT"}]}